Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11264278 | 0.89 | HTR1A (0.49) | KCNH2SIGMAR1SLC6A4ABCB1HTR7 | |
| SCHEMBL11275227 | 0.89 | KCNH2 (0.60) | KCNH2ADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL11290067 | 0.88 | HTR1A (0.59) | SIGMAR1SLC6A2SLC6A4SLC6A3HTR7 | |
| SCHEMBL11270622 | 0.88 | DRD3 (0.57) | KCNH2SIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL11283459 | 0.87 | KCNH2 (0.60) | KCNH2SIGMAR1ABCB1LMNA | |
| SCHEMBL11276248 | 0.87 | KCNH2 (0.57) | KCNH2ADRA1DADRA1AADRA1BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL11284442 | 0.87 | HTR1A (0.56) | KCNH2ADRA1ASIGMAR1HTR7HTR1A | |
| SCHEMBL11300075 | 0.86 | KCNH2 (0.62) | KCNH2ADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL11284128 | 0.85 | HTR7 (0.59) | SIGMAR1ABCB1HTR7DRD2HTR2A | |
| SCHEMBL11279327 | 0.84 | HTR1A (0.53) | KCNH2SIGMAR1SLC6A2SLC6A4HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |