Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.53 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | HRH1 | P35367 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11270622 | 0.96 | DRD3 (0.57) | HTR1ADRD3DRD2HRH1HTR2A | |
| Hydrochloric Acid SCHEMBL11284442 | 0.95 | HTR1A (0.56) | HTR1ADRD3DRD2HRH1HTR2A | |
| SCHEMBL11277199 | 0.91 | SLC6A2 (0.56) | HTR1ADRD3DRD2HRH1HTR2A | |
| SCHEMBL11273882 | 0.87 | DRD2 (0.55) | HTR1ADRD3DRD2HRH1HTR2A | |
| SCHEMBL11307110 | 0.87 | SLC6A4 (0.57) | HTR1ADRD3DRD2HTR2AHRH3 | |
| SCHEMBL11264278 | 0.86 | HTR1A (0.49) | HTR1ADRD3DRD2HRH1HTR2A | |
| SCHEMBL11290067 | 0.85 | HTR1A (0.59) | HTR1ADRD3DRD2HRH1HTR2A | |
| SCHEMBL11270171 | 0.84 | KCNH2 (0.57) | HTR1ADRD2HTR2ASIGMAR1KCNH2 | |
| SCHEMBL11284128 | 0.83 | HTR7 (0.59) | DRD3DRD2HTR2ASIGMAR1HTR7 | |
| SCHEMBL11292019 | 0.82 | TSHR (0.59) | HTR1ADRD3DRD2HRH1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |