Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275227 | 0.89 | KCNH2 (0.60) | KCNH2ABCB1SIGMAR1LMNA | |
| SCHEMBL11280762 | 0.88 | DRD3 (0.56) | SIGMAR1 | |
| SCHEMBL11270171 | 0.87 | KCNH2 (0.57) | KCNH2ABCB1SIGMAR1LMNA | |
| SCHEMBL11276248 | 0.87 | KCNH2 (0.57) | KCNH2ABCB1CHEK1SIGMAR1LMNA | |
| SCHEMBL11300075 | 0.86 | KCNH2 (0.62) | KCNH2ABCB1SIGMAR1 | |
| SCHEMBL11282244 | 0.85 | DRD2 (0.53) | SIGMAR1 | |
| SCHEMBL11276199 | 0.84 | KCNH2 (0.58) | KCNH2ABCB1SIGMAR1 | |
| SCHEMBL11270784 | 0.84 | KCNH2 (0.53) | KCNH2ABCB1SIGMAR1LMNA | |
| SCHEMBL11273685 | 0.83 | HTR2A (0.53) | LMNA | |
| SCHEMBL11282280 | 0.83 | ADRA1D (0.70) | KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |