Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHIT1 | Q13231 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11412037 | 0.84 | SIGMAR1 (0.46) | CHIT1HTTALDH1A1MAPTLMNA | |
| SCHEMBL11320624 | 0.84 | RAB9A (0.56) | HTTALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL11052921 | 0.84 | MEN1 (0.56) | HTTALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL11882906 | 0.84 | SIGMAR1 (0.50) | CHIT1HTTALDH1A1MAPTLMNA | |
| SCHEMBL11285564 | 0.82 | PKM (0.53) | HTTALDH1A1MAPTSMN1; SMN2MEN1 | |
| Methylamine SCHEMBL11259444 | 0.82 | SIGMAR1 (0.49) | CHIT1HTTALDH1A1MAPTLMNA | |
| SCHEMBL11320603 | 0.82 | CA1 (0.44) | HTTALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL11254202 | 0.82 | ALDH1A1 (0.46) | CHIT1HTTALDH1A1MAPTLMNA | |
| SCHEMBL11140703 | 0.82 | NOX1 (0.47) | CHIT1HTTALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11313322 | 0.82 | PYGL (0.55) | KMT2ANPSR1PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4216229-A | 1-AMIDINO-3-PHENYLUREAS | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4216230-A | Method for alleviating hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4150154-A | GASTROINTESTINAL ANTISPASMODICS | WILLIAM H. RORER, INC. (US) | 1979-04-17 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |