SCHEMBL11270733

SCHEMBL11270733

CCOC(=O)C(Cc1c[nH]c2cc(C)ccc12)(NC=O)C(=O)OCC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.43
HTR2A P28223 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.40
PKM P14618 1/20 0.39
ALKBH5 Q6P6C2 1/20 0.39
FTO Q9C0B1 1/20 0.39
NR3C1 P04150 2/20 0.38
NR3C2 P08235 1/20 0.38
PDE4D Q08499 2/20 0.38
SCN9A Q15858 1/20 0.37
ADAM17 P78536 1/20 0.37
MTNR1A P48039 1/20 0.37
MTNR1B P49286 1/20 0.37
NPC1 O15118 1/20 0.37
PDE4A P27815 1/20 0.37
PDE6C P51160 1/20 0.37
PDE4B Q07343 1/20 0.37
PDE4C Q08493 1/20 0.37
PDE10A Q9Y233 1/20 0.37
PCSK9 Q8NBP7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL838321 0.86 PKM (0.55) HTR2APKMCYP1A2CYP3A4CYP2D6
SCHEMBL23438306 0.83 TSHR (0.47) NR4A2HTR2AMTNR1AMTNR1B
SCHEMBL12585072 0.78 GPR84 (0.46) PKMALKBH5FTONR3C1NR3C2
SCHEMBL837253 0.76 MPO (0.45) L3MBTL1ALKBH5FTO
SCHEMBL837266 0.76 NR4A2 (0.44) NR4A2HTR2AL3MBTL1PDE4DPDE4A
SCHEMBL837438 0.76 ALDH1A1 (0.39) L3MBTL1PKMMTNR1AMTNR1BCYP1A2
SCHEMBL837919 0.75 MTNR1A (0.50) HTR2AL3MBTL1FTOMTNR1AMTNR1B
SCHEMBL14823139 0.73 PKM (0.70) NR4A2HTR2AL3MBTL1PKMPCSK9
SCHEMBL837466 0.72 MAPK1 (0.35) L3MBTL1PKMCYP2C9SMN1; SMN2MAPK1
SCHEMBL13911074 0.71 ALDH1A1 (0.60) PKMCYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4140697-A ARTIFICIAL SWEETENER HOFFMANN-LA ROCHE INC. (US) 1979-02-20 US claimed
US-4316847-A ARTIFICIAL SWEETENING HOFFMANN-LA ROCHE INC. (US) 1982-02-23 US disclosed
US-4256641-A ALKYL ALPHA-CARBOXAMIDOINDOLE-3-ACRYLATES MADE FROM 3-INDOLECARBOXALDEHYDES AND MONOALKYL CARBOXAMIDOMALONATES HOFFMANN-LA ROCHE INC. (US) 1981-03-17 US disclosed
US-4140697-A ARTIFICIAL SWEETENER HOFFMANN-LA ROCHE INC. (US) 1979-02-20 US disclosed
US-4073795-A Synthesis of tryptophans HOFFMANN-LA ROCHE INC. (US) 1978-02-14 US disclosed