Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | HCK | P08631 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 10/20 | 0.40 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11274435 | 0.77 | XDH (0.55) | DHFRKDRPIK3CAMTORPIK3CD | |
| SCHEMBL11401818 | 0.76 | DHFR (0.40) | DHFRHSP90AA1HSP90AB1PDE7AKDM4E | |
| SCHEMBL11277238 | 0.74 | PIK3CG (0.55) | KDRPIK3CAMTORPIK3CDABL1 | |
| SCHEMBL4222317 | 0.70 | TLR7 (0.47) | DHFRKDRPIK3CAMTORPIK3CD | |
| SCHEMBL11261653 | 0.69 | PDE5A (0.46) | PARP1 | |
| SCHEMBL5231538 | 0.68 | PDE5A (0.57) | PDE7AKDM4E | |
| SCHEMBL28234764 | 0.67 | PIK3CD (0.42) | KDRPIK3CAMTORPIK3CDABL1 | |
| SCHEMBL11401227 | 0.67 | BRD4 (0.37) | DHFRMTORHSP90AA1HSP90AB1PDE7A | |
| SCHEMBL11233557 | 0.67 | PDE5A (0.40) | PARP1 | |
| SCHEMBL28233679 | 0.66 | MAPT (0.56) | KDRPIK3CAMTORPIK3CDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4315932-A | AND SULFANILAMIDES | BURROUGHS WELLCOME CO. (US) | 1982-02-16 | — | — | US | disclosed |
| US-4288365-A | 1H-PYRIMIDO(4,5-C)-1,2-DIAZEPINES | BURROUGHS WELLCOME CO. (US) | 1981-09-08 | — | — | US | disclosed |
| US-4237289-A | MICROBIOCIDES | BURROUGHS WELLCOME CO. (US) | 1980-12-02 | — | — | US | disclosed |