Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275580 | 0.97 | KCNH2 (0.60) | KCNH2ABCB1SIGMAR1DRD2DRD4 | |
| SCHEMBL11273095 | 0.89 | DRD2 (0.58) | SIGMAR1DRD2DRD4DRD3HTR1A | |
| SCHEMBL11279326 | 0.88 | HTR1A (0.63) | KCNH2SIGMAR1DRD2DRD3HTR1A | |
| SCHEMBL11301941 | 0.87 | KCNH2 (0.59) | KCNH2ABCB1SIGMAR1DRD2HTR1A | |
| SCHEMBL11275248 | 0.87 | HTR1A (0.50) | ABCB1SIGMAR1DRD2DRD3HTR1A | |
| SCHEMBL11811688 | 0.87 | DRD2 (0.58) | SIGMAR1DRD2DRD4DRD3HTR1A | |
| SCHEMBL11276677 | 0.86 | KCNH2 (0.61) | KCNH2ABCB1DRD2DRD3HTR1A | |
| SCHEMBL11275227 | 0.86 | KCNH2 (0.60) | KCNH2ABCB1SIGMAR1DRD2DRD4 | |
| SCHEMBL11270602 | 0.86 | HTR1A (0.54) | SIGMAR1DRD2DRD4DRD3HTR1A | |
| SCHEMBL11809668 | 0.85 | HTR1A (0.63) | KCNH2SIGMAR1DRD2DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |