Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.53 |
| ▸ | HTR7 | P34969 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11297779 | 0.86 | DRD2 (0.55) | HTR2ADRD2HTR1AADRA1ASLC6A4 | |
| SCHEMBL11280762 | 0.85 | DRD3 (0.56) | HTR2ADRD2HTR1ADRD3HTR4 | |
| SCHEMBL11283459 | 0.83 | KCNH2 (0.60) | LMNA | |
| SCHEMBL11267243 | 0.82 | DRD2 (0.62) | HTR2AHTR7DRD2HTR1AADRA1A | |
| SCHEMBL11275076 | 0.81 | DRD2 (0.55) | HTR2ADRD2HTR1AADRA1ASLC6A4 | |
| SCHEMBL11273380 | 0.81 | FAAH (0.56) | HTR2AHTR7DRD2HTR1ADRD3 | |
| SCHEMBL8810414 | 0.80 | HTR2A (0.51) | HTR2ADRD2HTR1AADRA1A | |
| SCHEMBL11282244 | 0.80 | DRD2 (0.53) | HTR2AHTR7DRD2HTR1ADRD4 | |
| SCHEMBL11274506 | 0.79 | SLC6A2 (0.72) | DRD2ADRA1ASLC6A2SLC6A4DRD4 | |
| SCHEMBL11266439 | 0.79 | DRD2 (0.67) | HTR2AHTR7DRD2HTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |