SCHEMBL1127430

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4045529	0.82	TSHR (0.61)	KMT2AMEN1TSHRALDH1A1MAPT
	SCHEMBL1156156	0.79	NR4A2 (0.40)	KMT2ATSHRALDH1A1MAPTLMNA
	SCHEMBL4263806	0.78	KMT2A (0.45)	KMT2AMEN1TSHRALDH1A1MAPT
	SCHEMBL969677	0.77	TSHR (0.55)	KMT2AMEN1TSHRALDH1A1MAPT
	SCHEMBL7439372	0.77	KMT2A (0.61)	KMT2AMEN1TSHRALDH1A1MAPT
	SCHEMBL739464	0.76	TSHR (0.71)	KMT2AMEN1TSHRALDH1A1MAPT
	SCHEMBL1126625	0.76	ALDH1A1 (0.49)	KMT2AMEN1TSHRALDH1A1MAPT
	SCHEMBL4880908	0.76	TSHR (0.53)	KMT2AMEN1TSHRALDH1A1MAPT
	SCHEMBL4046233	0.76	TSHR (0.53)	KMT2AMEN1TSHRALDH1A1MAPT
	SCHEMBL31540155	0.76	KMT2A (0.58)	KMT2AMEN1TSHRALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.