Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.50 |
| ▸ | HTR2A | P28223 | 6/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | DRD3 | P35462 | 4/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11273977 | 0.90 | HTR1A (0.56) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL11279326 | 0.88 | HTR1A (0.63) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL11276199 | 0.87 | KCNH2 (0.58) | HTR1AHTR2ADRD2DRD3SIGMAR1 | |
| SCHEMBL11266147 | 0.87 | SLC6A2 (0.55) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL11276314 | 0.86 | HTR7 (0.59) | HTR2ADRD2DRD3SIGMAR1HTR7 | |
| SCHEMBL11276677 | 0.86 | KCNH2 (0.61) | HTR1AHTR2ADRD2DRD3HRH3 | |
| SCHEMBL11264278 | 0.86 | HTR1A (0.49) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL11809668 | 0.85 | HTR1A (0.63) | HTR1AHTR2ADRD2DRD3HRH1 | |
| SCHEMBL11814714 | 0.84 | HTR7 (0.57) | HTR2ADRD2DRD3SIGMAR1HTR7 | |
| SCHEMBL11270870 | 0.84 | HTR1A (0.59) | HTR1AHTR2ADRD2DRD3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |