Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | FUCA1 | P04066 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11302025 | 1.00 | TRPA1 (0.46) | TRPA1TRPM8EPHX1FUCA1ALDH1A1 | |
| SCHEMBL11304709 | 1.00 | TRPA1 (0.46) | TRPA1TRPM8EPHX1FUCA1ALDH1A1 | |
| SCHEMBL15454324 | 1.00 | TRPA1 (0.46) | TRPA1TRPM8EPHX1FUCA1ALDH1A1 | |
| SCHEMBL15462830 | 1.00 | TRPA1 (0.46) | TRPA1TRPM8EPHX1FUCA1ALDH1A1 | |
| SCHEMBL25365753 | 0.83 | TRPA1 (0.45) | TRPA1TRPM8EPHX1 | |
| SCHEMBL12166525 | 0.83 | TRPA1 (0.45) | TRPA1TRPM8EPHX1 | |
| SCHEMBL4640205 | 0.83 | TRPA1 (0.45) | TRPA1TRPM8EPHX1 | |
| SCHEMBL875599 | 0.79 | TRPA1 (0.42) | TRPA1TRPM8EPHX1 | |
| SCHEMBL875598 | 0.79 | TRPA1 (0.42) | TRPA1TRPM8EPHX1 | |
| SCHEMBL21630080 | 0.78 | TRPA1 (0.45) | TRPA1TRPM8EPHX1FUCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1245 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250163006-A1 | New Coolants, and Preparations Containing Same | SYMRISE AG (DE) | 2025-05-22 | — | — | US | claimed |
| US-20250066320-A1 | Active Ingredients with Sialagogue and Tingling/Fizzy Effect, and Preparations Containing Same | SYMRISE AG (DE) | 2025-02-27 | — | — | US | claimed |
| WO-2025026525-A1 | HETEROCYCLIC COMPOUNDS AS PHYSIOLOGICAL COOLANTS | SYMRISE AG (DE) | 2025-02-06 | — | — | WO | claimed |
| US-20250032500-A1 | REVITALIZING EYE DROPS | REVITALIZE ENERGY INC (US) | 2025-01-30 | — | — | US | claimed |
| EP-4469439-A1 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | Symrise AG (DE) | 2024-12-04 | — | — | EP | claimed |
| CN-118984825-A | Novel cooling agent and preparation containing same | 西姆莱斯股份公司 | 2024-11-19 | — | — | CN | claimed |
| EP-4452941-A1 | ACTIVE INGREDIENTS WITH SIALAGOGUE AND TINGLING/FIZZY EFFECT, AND PREPARATIONS CONTAINING SAME | Symrise AG (DE) | 2024-10-30 | — | — | EP | claimed |
| EP-4442241-A2 | RETINOL REPLACEMENT IN SKIN TREATMENT | Symrise AG (DE) | 2024-10-09 | — | — | EP | claimed |
| EP-3773445-B1 | RETINOL REPLACEMENT IN SKIN TREATMENT | SYMRISE AG (DE) | 2024-07-24 | — | — | EP | claimed |
| US-20240058259-A1 | COMPOSITIONS COMPRISING ESSENTIAL OILS | FIRMENICH SA (CH) | 2024-02-22 | — | — | US | claimed |
| US-20070148103-A1 | Compositions providing a heating sensation for oral or dermal delivery | CADBURY ADAMS USA, LLC. | 2007-06-28 | — | — | US | claimed |
| WO-2007062957-A1 | MIXTURES COMPRISING ANTHRANILIC ACID AMIDES AND ANTIDANDRUFF AGENTS AS COSMETIC AND PHARMACEUTICAL COMPOSITIONS FOR ALLEVIATING ITCHING | SYMRISE GMBH & CO. KG (DE) | 2007-06-07 | — | — | WO | claimed |
| WO-2006127738-A9 | COMPRESSIBLE CHEWING GUMS FOR DELIVERY OF ACTIVES | CADBURY ADAMS USA LLC (US) | 2007-05-31 | — | — | WO | claimed |
| EP-1446019-B1 | WATER CONTINUOUS FOOD PRODUCT WITH COOLING FLAVOUR | UNILEVER NV (NL) | 2007-03-14 | — | — | EP | claimed |
| WO-2006127740-A2 | INDICIA-BEARING PACKAGE FOR DELIVERY SYSTEMS FOR MANAGING RELEASE OF SWEETENERS, SENSATES, FUNCTIONAL INGREDIENTS, FOOD ACIDS AND FLAVORS IN A COMPRESSIBLE GUM SYSTEM | CADBURY ADAMS USA LLC (US) | 2006-11-30 | — | — | WO | claimed |
| WO-2006127738-A2 | COMPRESSIBLE CHEWING GUMS FOR DELIVERY OF ACTIVES | CADBURY ADAMS USA LLC (US) | 2006-11-30 | — | — | WO | claimed |
| US-20050013846-A1 | Water continuous food product with cooling flavour | UNILEVER BESTFOODS, NORTH AMERICA, DIVISION OF CONOPCO, INC. | 2005-01-20 | — | — | US | claimed |
| US-6838106-B2 | Warming composition for food and drink or for oral care preparation | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2005-01-04 | — | — | US | claimed |
| EP-1446019-A1 | WATER CONTINUOUS FOOD PRODUCT WITH COOLING FLAVOUR | UNILEVER N.V. (NL) | 2004-08-18 | — | — | EP | claimed |
| WO-2003043431-A1 | WATER CONTINUOUS FOOD PRODUCT WITH COOLING FLAVOUR | UNILEVER N.V. (NL) | 2003-05-30 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070148103-A1 | Compositions providing a heating sensation for oral or dermal delivery | TAS2R8, TAS2R60, TAS2R20 | TRPA1 37/4885TRPM8 25/4885EPHX1 3821/4885 |
| US-20250066320-A1 | Active Ingredients with Sialagogue and Tingling/Fizzy Effect, and Preparations Containing Same | TAS2R5, TAS2R7, TAS2R8 | TRPA1 1499/4885TRPM8 363/4885EPHX1 2617/4885 |
| US-20250163006-A1 | New Coolants, and Preparations Containing Same | TTR, TAS2R5, TAS2R50 | TRPA1 185/4885TRPM8 152/4885EPHX1 2081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.