Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.54 |
| ▸ | SNCA | P37840 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TOP1 | P11387 | 2/20 | 0.48 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DDX3X | O00571 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109020 | 0.87 | ALOX15 (0.66) | ALOX15SNCATOP1ERCC1ERCC4 | |
| SCHEMBL13804531 | 0.80 | ALDH1A1 (0.55) | ALOX15SNCAALDH1A1TOP1ERCC1 | |
| SCHEMBL19427497 | 0.80 | ALOX15 (0.63) | ALOX15SNCAALDH1A1TOP1ERCC1 | |
| SCHEMBL6222775 | 0.79 | PEPD (0.59) | ALOX15SNCAALDH1A1TOP1ERCC1 | |
| SCHEMBL107966 | 0.79 | SNCA (0.56) | ALOX15SNCAALDH1A1TOP1ERCC1 | |
| SCHEMBL13772128 | 0.78 | ALOX15 (0.71) | ALOX15ERCC1ERCC4MAOAMAOB | |
| SCHEMBL11275768 | 0.78 | PYGL (0.49) | ALOX15SNCATOP1ERCC1ERCC4 | |
| SCHEMBL24784814 | 0.78 | SMN1; SMN2 (0.42) | ALOX15SNCAALDH1A1PYGLPIM1 | |
| SCHEMBL18155290 | 0.77 | ALOX15 (0.55) | ALOX15SNCAALDH1A1TOP1ERCC1 | |
| SCHEMBL9675109 | 0.77 | ALOX15 (0.51) | ALOX15SNCATOP1ERCC1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251143-B1 | 2-Oxo-1-[[(Substituted Sulfonyl)Amino]-Carbonyl]Azetidines | Bristol-Myers Squibb GmbH (DE) | 1992-08-26 | — | — | EP | disclosed |
| US-4801705-A | 2-oxo-1-(((substituted sulfonyl)amino)-carbonyl)azetidines | E. R. SQUIBB & SONS, INC. (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0251143-A1 | 2-Oxo-1-[[(Substituted Sulfonyl)Amino]-Carbonyl]Azetidines | Bristol-Myers Squibb GmbH (DE) | 1988-01-07 | — | — | EP | disclosed |