Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11438620 | 0.94 | CHRNB2 (0.58) | CHRNB2CHRNA4HIF1AKDM4ELMNA | |
| SCHEMBL11275931 | 0.91 | TSHR (0.53) | CHRNB2CHRNA4HIF1AKDM4ELMNA | |
| SCHEMBL11273462 | 0.90 | LMNA (0.59) | HIF1AKDM4ELMNAMAPK1KDM1A | |
| SCHEMBL10346705 | 0.76 | ALDH1A1 (0.61) | CHRNB2CHRNA4HIF1AMAPK1PRMT5 | |
| SCHEMBL11280123 | 0.75 | ADRB3 (0.64) | ADRB3PTGS1SLC6A2KMT2AMEN1 | |
| SCHEMBL11272311 | 0.75 | KMT2A (0.48) | HIF1AADRB3PTGS1SLC6A2KMT2A | |
| SCHEMBL22207338 | 0.74 | ADRB3 (0.55) | CHRNB2CHRNA4HIF1AKDM4EMAPK1 | |
| SCHEMBL29591093 | 0.74 | CHRNB2 (1.00) | CHRNB2CHRNA4KDM4ELMNAKMT2A | |
| SCHEMBL1957431 | 0.74 | CHRNB2 (1.00) | CHRNB2CHRNA4KDM4ELMNAKMT2A | |
| SCHEMBL22207426 | 0.73 | HIF1A (0.51) | CHRNB2CHRNA4HIF1AKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064487-A1 | New substituted 3-(parasubstituted)phenoxy-1-alkylamino-propanol-2-s, as well as process for their preparation, pharmaceutical preparations containing same, and method for treating cardiac failure | Aktiebolaget Hässle (SE) | 1982-11-10 | — | — | EP | disclosed |