Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11276906 | 0.94 | CHRNB2 (0.57) | CHRNB2CHRNA4KDM4ELMNAMAPK1 | |
| SCHEMBL11273462 | 0.88 | LMNA (0.59) | KDM4ELMNAMAPK1HIF1AKDM1A | |
| SCHEMBL11275931 | 0.84 | TSHR (0.53) | CHRNB2CHRNA4KDM4ELMNAMAPK1 | |
| SCHEMBL10346705 | 0.82 | ALDH1A1 (0.61) | CHRNB2CHRNA4MAPK1HIF1APRMT5 | |
| SCHEMBL12212607 | 0.78 | KDM4E (0.59) | KDM4ELMNAMAPK1HIF1AKDM1A | |
| SCHEMBL10838063 | 0.77 | HIF1A (0.51) | KDM4ELMNAMAPK1HIF1APRMT5 | |
| SCHEMBL15296872 | 0.76 | POLB (0.53) | KDM4ELMNAMAPK1HIF1AKDM1A | |
| SCHEMBL22207338 | 0.75 | ADRB3 (0.55) | CHRNB2CHRNA4KDM4EMAPK1HIF1A | |
| SCHEMBL10836817 | 0.75 | LMNA (0.49) | KDM4ELMNAMAPK1HIF1APRMT5 | |
| SCHEMBL1957431 | 0.75 | CHRNB2 (1.00) | CHRNB2CHRNA4KDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0006614-A2 | Pyridyl- and imidazopyridyloxypropanolamines, process for preparing the same and pharmaceutical compositions containing the same | MERCK & CO. INC. (US) | 1980-01-09 | — | — | EP | disclosed |