Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 9/20 | 0.38 |
| ▸ | MAOB | P27338 | 9/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11280720 | 0.81 | DRD2 (0.46) | MAOAMAOBCRBNNPC1MAPK13 | |
| SCHEMBL6588791 | 0.80 | CCR1 (0.41) | MAOAMAOBCRBNNPC1MAPK13 | |
| SCHEMBL10774435 | 0.79 | NPC1 (0.39) | MAOAMAOBNPC1MAPK13MAPK12 | |
| SCHEMBL11277246 | 0.79 | MAOA (0.41) | MAOAMAOBCRBNBRD4NPC1 | |
| SCHEMBL10925770 | 0.78 | MAOA (0.36) | MAOAMAOBBRD4NPC1MAPK13 | |
| SCHEMBL11278612 | 0.77 | LMNA (0.46) | MAOAMAOBNPC1MAPK13MAPK12 | |
| SCHEMBL11281049 | 0.76 | NPC1 (0.38) | MAOAMAOBBRD4NPC1MAPK13 | |
| SCHEMBL11276496 | 0.75 | MAOB (0.69) | MAOAMAOBDRD2 | |
| SCHEMBL11015880 | 0.75 | MAOB (0.69) | MAOAMAOBDRD2 | |
| SCHEMBL12090742 | 0.74 | CYP19A1 (0.48) | CRBNBRD4NPC1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003771-B1 | CARBOSTYRILE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-10-20 | — | — | EP | disclosed |
| US-4329347-A | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril | BOEHRINGER INGELHEIM GMBH (DE) | 1982-05-11 | — | — | US | disclosed |
| EP-0003771-A1 | Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1979-09-05 | — | — | EP | disclosed |