Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 4/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 2/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11553823 | 0.88 | ADRB2 (0.42) | DRD2DRD4DRD3ADRB2ADRB1 | |
| SCHEMBL9653685 | 0.82 | ADRB1 (0.51) | DRD2DRD4DRD3ADRB2ADRB1 | |
| SCHEMBL30335516 | 0.81 | ADRB1 (0.50) | DRD2DRD4DRD3ADRB2ADRB1 | |
| SCHEMBL9653135 | 0.81 | ADRB1 (0.50) | DRD2DRD4DRD3ADRB2ADRB1 | |
| SCHEMBL11278014 | 0.81 | MAOA (0.38) | DRD2MAOAMAOBCRBNCYP1A2 | |
| SCHEMBL9653164 | 0.80 | ADRB1 (0.52) | DRD2DRD4DRD3ADRB2ADRB1 | |
| SCHEMBL11479869 | 0.80 | ADRB2 (0.50) | DRD2DRD4DRD3ADRB2ADRB1 | |
| SCHEMBL11281585 | 0.80 | ADRB1 (0.49) | DRD2DRD4DRD3ADRB2ADRB1 | |
| SCHEMBL18072426 | 0.79 | ADRB2 (0.54) | DRD2DRD4DRD3ADRB2ADRB1 | |
| SCHEMBL11272012 | 0.79 | ADRB1 (0.61) | DRD2DRD4DRD3ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003771-B1 | CARBOSTYRILE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-10-20 | — | — | EP | disclosed |
| US-4329347-A | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril | BOEHRINGER INGELHEIM GMBH (DE) | 1982-05-11 | — | — | US | disclosed |
| EP-0003771-A1 | Carbostyrile derivatives, their preparation and pharmaceutical compositions containing them | Dr. Karl Thomae GmbH (DE) | 1979-09-05 | — | — | EP | disclosed |