SCHEMBL11278091

SCHEMBL11278091

COc1c(Cl)cc(N2C(=N)CN(C)C2=O)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.33
KDM4E B2RXH2 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
TSHR P16473 1/20 0.33
GAA P10253 2/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
LY96 Q9Y6Y9 1/20 0.32
HPGD P15428 1/20 0.31
CYP19A1 P11511 1/20 0.31
NQO2 P16083 1/20 0.31
MAPT P10636 1/20 0.31
NFE2L2 Q16236 1/20 0.31
USP2 O75604 1/20 0.31
HTR1A P08908 1/20 0.31
DRD2 P14416 1/20 0.31
DRD4 P21917 1/20 0.31
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11271240 0.91 KDM4E (0.30) ALDH1A1KDM4ESMN1; SMN2TSHR
SCHEMBL11280801 0.82 ALDH1A1 (0.48) ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A
SCHEMBL11278830 0.81 TSHR (0.43) ALDH1A1KDM4ESMN1; SMN2TSHRUSP2
SCHEMBL10874965 0.79 KMT2A (0.47) ALDH1A1KDM4ESMN1; SMN2MEN1KMT2A
SCHEMBL11268915 0.78 ALDH1A1 (0.54) ALDH1A1KDM4ESMN1; SMN2GAAMEN1
SCHEMBL11276928 0.75 KMT2A (0.50) ALDH1A1SMN1; SMN2GAAMEN1KMT2A
SCHEMBL11270496 0.73 ELANE (0.44) ALDH1A1SMN1; SMN2MEN1KMT2AMAPT
SCHEMBL11271202 0.73 HTR7 (0.45) ALDH1A1SMN1; SMN2TSHRKMT2AL3MBTL1
SCHEMBL11267668 0.73 KMT2A (0.49) ALDH1A1KDM4ESMN1; SMN2TSHRGAA
SCHEMBL11267472 0.72 RAD51 (0.42) ALDH1A1KDM4ESMN1; SMN2GAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0024570-B1 5-IMINO-IMIDAZOLINE-2-ONES, HERBICIDES CONTAINING THEM AND PROCESS FOR DESTRUCTING UNDESIRED PLANTS BASF Aktiengesellschaft (DE) 1982-05-12 EP disclosed