Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.61 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.61 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MAOA | P21397 | 2/20 | 0.59 |
| ▸ | MAOB | P27338 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.59 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16553440 | 0.90 | ALDH1A1 (0.65) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| Dibemethine SCHEMBL10542007 | 0.89 | ALDH1A1 (0.70) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| Dibemethine SCHEMBL276863 | 0.89 | ALDH1A1 (0.70) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| Dibemethine SCHEMBL2139708 | 0.86 | ALDH1A1 (0.67) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL7055109 | 0.84 | CARM1 (0.75) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL29733117 | 0.83 | SIGMAR1 (0.85) | CARM1PRMT6PRMT8SIGMAR1LMNA | |
| SCHEMBL7225346 | 0.83 | SIGMAR1 (0.85) | CARM1PRMT6PRMT8SIGMAR1LMNA | |
| SCHEMBL355111 | 0.82 | TSHR (0.61) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| SCHEMBL22305213 | 0.82 | KDM4E (0.61) | ALDH1A1TSHRCARM1PRMT6PRMT8 | |
| Iodide SCHEMBL6672021 | 0.81 | TSHR (0.94) | ALDH1A1TSHRCARM1PRMT6PRMT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4397652-A2 | 3-(PHENYL)-2-(AMINOMETHYL)-1-PHENYL-2-PROPEN-1-ONE DERIVATIVES AS INHIBITORS OF THE N-TERMINAL DOMAIN OF THE ANDROGEN RECEPTOR FOR TREATING PROSTATE CANCER | The Regents of the University of California (US) | 2024-07-10 | — | — | EP | disclosed |
| CN-110325508-B | Inhibitors of the N-terminal domain of androgen receptor | 加利福尼亚大学董事会 | 2023-06-30 | — | — | CN | disclosed |
| WO-2018136792-A1 | INHIBITORS OF THE N-TERMINAL DOMAIN OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-07-26 | — | — | WO | disclosed |
| EP-3219706-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | Fibrogen, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| US-9708269-B2 | Process for making isoquinoline compounds | FIBROGEN, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| US-9708269-B2 | Process for making isoquinoline compounds | FIBROGEN, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| EP-2872487-B1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | FIBROGEN INC (US) | 2017-04-26 | — | — | EP | disclosed |
| US-20160194285-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | FIBROGEN, INC. | 2016-07-07 | — | — | US | disclosed |
| US-20160194285-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | FIBROGEN, INC. | 2016-07-07 | — | — | US | disclosed |
| US-9340511-B2 | Process for making isoquinoline compounds | FIBROGEN, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-9340511-B2 | Process for making isoquinoline compounds | FIBROGEN, INC. (US) | 2016-05-17 | — | — | US | disclosed |
| US-20150175550-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | FIBROGEN, INC. | 2015-06-25 | — | — | US | disclosed |
| US-20150175550-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | FIBROGEN, INC. | 2015-06-25 | — | — | US | disclosed |
| EP-0013749-B1 | HEXAHYDRO-1,4-OXAZEPINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1982-05-12 | — | — | EP | disclosed |
| US-4269833-A | 7-/3-HYDROXY-, OXY-, OR CARBONYLOXY-SUBSTITUTED/PHENYL DERIVATIVES; ANALGESICS | BASF AKTIENGESELLSCHAFT (DE) | 1981-05-26 | — | — | US | disclosed |
| EP-0013749-A1 | Hexahydro-1,4-oxazepines, process for their preparation and pharmaceutical compositions containing them | BASF Aktiengesellschaft (DE) | 1980-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175550-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | HIF1AN, HIF1A, EGLN3 | ALDH1A1 421/4885TSHR 4432/4885CARM1 779/4885 |
| US-20160194285-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | HIF1AN, HIF1A, EGLN3 | ALDH1A1 421/4885TSHR 4432/4885CARM1 779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.