SCHEMBL1127954

SCHEMBL1127954

CCCCCCCCCCCCCCCCCCOC(C)(C[N+](C)(C)C)OCCCCCCCCCCCCCCCCCC

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNM1 Q05193 7/20 0.39
RAD52 P43351 2/20 0.39
NPSR1 Q6W5P4 1/20 0.39
LMNA P02545 1/20 0.37
ESR1 P03372 1/20 0.37
ADORA3 P0DMS8 1/20 0.37
CDC25A P30304 1/20 0.37
AGTR1 P30556 1/20 0.37
AKT1 P31749 1/20 0.37
ADRA1A P35348 1/20 0.37
KCNH2 Q12809 1/20 0.37
APAF1 O14727 1/20 0.37
HSP90AA1 P07900 1/20 0.37
PRKD3 O94806 1/20 0.36
PRKCG P05129 1/20 0.36
PRKCB P05771 1/20 0.36
PRKCA P17252 1/20 0.36
PRKCH P24723 1/20 0.36
PRKCI P41743 1/20 0.36
PRKCE Q02156 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6831358 0.91 LPAR2 (0.44)
SCHEMBL1906179 0.91 LPAR2 (0.44)
Hydrochloric Acid SCHEMBL7147494 0.89 LPAR2 (0.42)
Hydrochloric Acid SCHEMBL28430115 0.82 DNM1 (0.38) DNM1RAD52NPSR1LMNAESR1
SCHEMBL12257499 0.78 LPAR3 (0.41) HTTTHRBTSHRMEN1KMT2A
SCHEMBL12257497 0.78 LPAR3 (0.41) HTTTHRBTSHRMEN1KMT2A
SCHEMBL872445 0.78 CES2 (0.35) DNM1RAD52NPSR1LMNAESR1
SCHEMBL11508110 0.76 THRB (0.38) HTTTHRBTSHRMEN1KMT2A
SCHEMBL15554489 0.76 THRB (0.38) HTTTHRBTSHRMEN1KMT2A
SCHEMBL6021113 0.74 MEN1 (0.45) LMNAHTTTHRBTSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023196742-A9 ANTI-CD90 ANTIBODIES, BINDING FRAGMENTS, AND USES THEREOF FRED HUTCHINSON CANCER CENTER (US) 2024-07-11 WO disclosed
WO-2023196742-A1 ANTI-CD90 ANTIBODIES, BINDING FRAGMENTS, AND USES THEREOF FRED HUTCHINSON CANCER CENTER (US) 2023-10-12 WO disclosed
EP-3787996-A1 NANOPARTICLES FOR GENE EXPRESSION AND USES THEREOF Fred Hutchinson Cancer Research Center (US) 2021-03-10 EP disclosed
EP-3740198-A1 ALTERING INFLAMMATORY STATES OF IMMUNE CELLS IN VIVO BY MODULATING CELLULAR ACTIVATION STATES Fred Hutchinson Cancer Research Center (US) 2020-11-25 EP disclosed
WO-2020191060-A2 CIRCUMSPOROZOITE PROTEINS WITH INCREASED EXPRESSION IN MAMMALIAN CELLS FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2020-09-24 WO disclosed
EP-3565535-A1 SYSTEMS AND METHODS TO IMPROVE VACCINE EFFICACY Fred Hutchinson Cancer Research Center (US) 2019-11-13 EP disclosed
WO-2019143948-A1 ALTERING INFLAMMATORY STATES OF IMMUNE CELLS IN VIVO BY MODULATING CELLULAR ACTIVATION STATES FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2019-07-25 WO disclosed
EP-3442585-A1 COMPOSITIONS AND METHODS TO PROGRAM THERAPEUTIC CELLS USING TARGETED NUCLEIC ACID NANOCARRIERS Fred Hutchinson Cancer Research Center (US) 2019-02-20 EP disclosed
WO-2018129270-A1 SYSTEMS AND METHODS TO IMPROVE VACCINE EFFICACY FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2018-07-12 WO disclosed
WO-2017181110-A1 COMPOSITIONS AND METHODS TO PROGRAM THERAPEUTIC CELLS USING TARGETED NUCLEIC ACID NANOCARRIERS FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2017-10-19 WO disclosed
EP-2282724-A2 MODIFIED DRUGS FOR USE IN LIPOSOMAL NANOPARTICLES The University Of British Columbia (CA) 2011-02-16 EP disclosed
WO-2009141738-A2 MODIFIED DRUGS FOR USE IN LIPOSOMAL NANOPARTICLES THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2009-11-26 WO disclosed