Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14478788 | 0.86 | RAB9A (0.64) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11280137 | 0.77 | EGFR (0.56) | NPC1RAB9AKDM4ETDP1L3MBTL1 | |
| SCHEMBL11284523 | 0.75 | KDM4E (0.50) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL11983218 | 0.75 | SERPINE1 (0.51) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL11292150 | 0.73 | KDM4E (0.50) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL11285157 | 0.73 | EGFR (0.49) | NPC1RAB9AKDM4EMAPTMEN1 | |
| SCHEMBL8805502 | 0.73 | MAPK1 (0.44) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL11291470 | 0.73 | ADORA3 (0.55) | NPC1RAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL11983194 | 0.73 | L3MBTL1 (0.63) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL11282857 | 0.73 | ROCK2 (0.47) | NPC1RAB9AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059698-A1 | Heterocyclic carboxamides, compositions containing such compounds, processes for their preparation and methods of treatment therewith | AB LEO (SE) | 1982-09-08 | — | — | EP | disclosed |