Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | LIPE | Q05469 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30892449 | 0.84 | MAPT (0.51) | MAPTL3MBTL1MAPK1TDP1HTR1A | |
| SCHEMBL11605666 | 0.84 | MAPT (0.51) | MAPTL3MBTL1MAPK1TDP1HTR1A | |
| SCHEMBL16855019 | 0.79 | MAPT (0.50) | MAPTL3MBTL1MAPK1TDP1HTR1A | |
| SCHEMBL339812 | 0.75 | MAPT (0.71) | MAPTL3MBTL1MAPK1TDP1HTR1A | |
| SCHEMBL16347731 | 0.74 | RAB9A (0.46) | MAPTL3MBTL1MAPK1TDP1HTR1A | |
| SCHEMBL30041677 | 0.74 | KDM1A (0.52) | MAPTL3MBTL1MAPK1TDP1HTR1A | |
| SCHEMBL416462 | 0.74 | MAPT (0.57) | MAPTL3MBTL1MAPK1TDP1HTR1A | |
| SCHEMBL29380769 | 0.74 | MAPT (0.57) | MAPTL3MBTL1MAPK1TDP1HTR1A | |
| SCHEMBL31643697 | 0.73 | LMNA (0.47) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9007487 | 0.72 | MAPT (0.80) | MAPTL3MBTL1MAPK1TDP1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007403-B1 | 5,12-DIHYDROXY-1,2,3,4,6,11-HEXAHYDRO-2,6,11-TRIOXONAPHTHACENES AND THEIR SYNTHESIS | THE UNIVERSITY OF KANSAS (US) | 1982-11-24 | — | — | EP | claimed |
| US-4244880-A | Anthracycline synthesis | UNIVERSITY OF KANSAS ENDOWMENT ASSOCIATION (US) | 1981-01-13 | — | — | US | claimed |
| EP-0007403-A1 | 5,12-dihydroxy-1,2,3,4,6,11-hexahydro-2,6,11-trioxonaphthacenes and their synthesis | THE UNIVERSITY OF KANSAS (US) | 1980-02-06 | — | — | EP | claimed |
| EP-0007403-B1 | 5,12-DIHYDROXY-1,2,3,4,6,11-HEXAHYDRO-2,6,11-TRIOXONAPHTHACENES AND THEIR SYNTHESIS | THE UNIVERSITY OF KANSAS (US) | 1982-11-24 | — | — | EP | disclosed |
| EP-0043435-A1 | Intermediate products occurring in anthracycline synthesis | THE UNIVERSITY OF KANSAS (US) | 1982-01-13 | — | — | EP | disclosed |
| US-4244880-A | Anthracycline synthesis | UNIVERSITY OF KANSAS ENDOWMENT ASSOCIATION (US) | 1981-01-13 | — | — | US | disclosed |
| EP-0007404-A1 | Synthesis of 2-hydroxy-2-acetyl-1,2,3,4-tetrahydronaphthalene compounds | THE UNIVERSITY OF KANSAS (US) | 1980-02-06 | — | — | EP | disclosed |
| EP-0007403-A1 | 5,12-dihydroxy-1,2,3,4,6,11-hexahydro-2,6,11-trioxonaphthacenes and their synthesis | THE UNIVERSITY OF KANSAS (US) | 1980-02-06 | — | — | EP | disclosed |