Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.74 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.69 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6282345 | 0.92 | PTGS2 (0.68) | PTGS2ALOX5PTGDR2 | |
| SCHEMBL9768642 | 0.89 | ALDH1A1 (0.62) | PTGS2ALOX5PTGDR2ALDH1A1CYP1A2 | |
| SCHEMBL7845380 | 0.86 | PTGS2 (0.77) | PTGS2ALOX5PTGS1 | |
| SCHEMBL7832424 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL21670773 | 0.84 | PTGS2 (0.56) | PTGS2ALOX5PTGDR2ALDH1A1CYP1A2 | |
| SCHEMBL11460695 | 0.83 | KDM4E (0.58) | PTGS2ALOX5PTGDR2ALDH1A1CYP1A2 | |
| SCHEMBL11284205 | 0.83 | KDM4E (0.58) | PTGS2ALOX5PTGDR2ALDH1A1CYP1A2 | |
| SCHEMBL12245630 | 0.83 | ALOX5 (0.69) | PTGS2ALOX5PTGS1ALDH1A1CYP1A2 | |
| SCHEMBL11462189 | 0.83 | KDM4E (0.58) | PTGS2ALOX5PTGDR2ALDH1A1CYP1A2 | |
| SCHEMBL10506565 | 0.82 | PTGS2 (0.78) | PTGS2ALOX5PTGDR2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322428-A | 2(4-Fluorophenyl)-4,5,-bis(4-methoxyphenyl)thiazole and method of use | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| EP-0037274-A1 | Substituted triaryl thiazole compounds | ELI LILLY AND COMPANY (US) | 1981-10-07 | — | — | EP | disclosed |