Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 9/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.43 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497217 | 0.83 | HPGD (0.58) | ALDH1A1MAPTHPGD | |
| SCHEMBL7790315 | 0.82 | PARP10 (0.48) | PARP10CA2PARP4PARP1CA1 | |
| SCHEMBL925065 | 0.81 | TSHR (0.52) | CA2CA1ALDH1A1KMT2ATSHR | |
| SCHEMBL960521 | 0.79 | MPO (0.52) | CA2CA1ALDH1A1KMT2AMAPT | |
| SCHEMBL2852148 | 0.77 | MAPT (0.49) | PARP10CA2PARP4PARP1CA1 | |
| SCHEMBL20438385 | 0.76 | ALDH1A1 (0.39) | HSD17B10ALDH1A1TSHRCYP3A4TDP1 | |
| Hydrochloric Acid SCHEMBL4867978 | 0.76 | MAPT (0.48) | PARP10CA2PARP4PARP1CA1 | |
| SCHEMBL632045 | 0.76 | ALDH1A1 (0.67) | PARP10CA2PARP4PARP1CA1 | |
| Bicarbonate SCHEMBL6665758 | 0.75 | ALDH1A1 (0.43) | ALDH1A1TSHRMAPTL3MBTL1CYP3A4 | |
| SCHEMBL2882577 | 0.75 | NPSR1 (0.54) | PARP10CA2PARP4PARP1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153803-B2 | Compositions and methods for modulating sirtuin activity | THE GENERAL HOSPITAL CORPORATION (US) | 2012-04-10 | — | — | US | disclosed |
| US-20090259044-A1 | COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY | THE GENERAL HOSPITAL CORPORATION (US) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090259044-A1 | COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY | SIRT2, SIRT1, SIRT3 | PARP10 175/4885CA2 3490/4885PARP4 757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.