Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 11/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10288373 | 0.85 | IRAK4 (0.47) | TSHRL3MBTL1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL3521281 | 0.81 | TSHR (0.66) | TSHRL3MBTL1LMNANPSR1CYP1A2 | |
| SCHEMBL12165506 | 0.80 | TSHR (0.52) | TSHRL3MBTL1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL4414857 | 0.80 | TSHR (1.00) | TSHRL3MBTL1LMNASMN1; SMN2MAPT | |
| SCHEMBL31090837 | 0.79 | CCR2 (0.68) | TSHRL3MBTL1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL1758548 | 0.77 | KMT2A (0.57) | TSHRL3MBTL1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL8787198 | 0.76 | L3MBTL1 (0.64) | L3MBTL1LMNANPSR1SMN1; SMN2MAPT | |
| SCHEMBL23418697 | 0.76 | LMNA (0.62) | L3MBTL1LMNANPSR1SMN1; SMN2MAPT | |
| SCHEMBL30933708 | 0.76 | LMNA (0.62) | L3MBTL1LMNANPSR1SMN1; SMN2MAPT | |
| SCHEMBL21305526 | 0.75 | PNLIP (0.54) | TSHRPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481733-B2 | Substituted imidazopyr- and imidazotri-azines | OSI Pharmaceuticals, LLC (US) | 2013-07-09 | — | — | US | disclosed |
| EP-2283020-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI Pharmaceuticals, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| US-7737136-B2 | Non-steroidal progesterone receptor modulators | N.V. ORGANON (NL) | 2010-06-15 | — | — | US | disclosed |
| US-7737136-B2 | Non-steroidal progesterone receptor modulators | N.V. ORGANON (NL) | 2010-06-15 | — | — | US | disclosed |
| US-7737136-B2 | Non-steroidal progesterone receptor modulators | N.V. ORGANON (NL) | 2010-06-15 | — | — | US | disclosed |
| WO-2009143051-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |
| US-20090286768-A1 | SUBSTITUTED IMIDAZOPYR- AND IMIDAZOTRI-AZINES | OSI PHARMACEUTICALS, INC. (US) | 2009-11-19 | — | — | US | disclosed |
| EP-1495030-B1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | ORGANON NV (NL) | 2008-08-13 | — | — | EP | disclosed |
| EP-1495030-B1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | ORGANON NV (NL) | 2008-08-13 | — | — | EP | disclosed |
| CN-1279044-C | Non-steroidal progesterone receptor modulators | AKZO NOBEL NV (NL) | 2006-10-11 | — | — | CN | disclosed |
| US-20050171087-A1 | Non-steroidal progesterone receptor modulators | MERCK SHARP & DOHME B.V. (NL) | 2005-08-04 | — | — | US | disclosed |
| CN-1649879-A | Non-steroidal progesterone receptor modulators | AKZO NOBEL NV (NL) | 2005-08-03 | — | — | CN | disclosed |
| EP-1495030-A1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | Akzo Nobel N.V. (NL) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003084963-A1 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS | AKZO NOBEL N.V. (NL) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286768-A1 | SUBSTITUTED IMIDAZOPYR- AND IMIDAZOTRI-AZINES | ABL1, TPMT, CYP2C19 | TSHR 902/4885L3MBTL1 4613/4885LMNA 3418/4885 |
| US-20050171087-A1 | Non-steroidal progesterone receptor modulators | PGR, PGRMC1, PGRMC2 | TSHR 200/4885L3MBTL1 4849/4885LMNA 4247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.