Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 12/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10915401 | 0.79 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BOPRM1OPRD1 | |
| SCHEMBL6746046 | 0.74 | KDM4E (0.60) | ADRA1DADRA1AADRA1BOPRM1OPRD1 | |
| SCHEMBL16719018 | 0.70 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BOPRM1OPRD1 | |
| SCHEMBL16719017 | 0.70 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BOPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL10915399 | 0.70 | OPRM1 (0.56) | ADRA1AOPRM1OPRD1KCNA3OPRK1 | |
| SCHEMBL10924212 | 0.69 | SLC6A12 (0.53) | DRD2KDM4ENPSR1 | |
| SCHEMBL10567213 | 0.68 | OPRM1 (0.53) | ADRA1DADRA1AADRA1BOPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL10919520 | 0.67 | OPRM1 (0.39) | OPRM1OPRD1DRD2DRD3OPRK1 | |
| SCHEMBL373427 | 0.67 | SLC6A12 (0.53) | — | |
| SCHEMBL6961790 | 0.67 | KCNA3 (0.63) | ADRA1DADRA1AADRA1BOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064707-A1 | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |