Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 10/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10915399 | 0.90 | OPRM1 (0.56) | ADRA1AOPRM1OPRD1KCNA3OPRK1 | |
| Hydrochloric Acid SCHEMBL10919520 | 0.89 | OPRM1 (0.39) | OPRM1OPRD1DRD2DRD3OPRK1 | |
| Hydrochloric Acid SCHEMBL10918932 | 0.81 | OPRM1 (0.52) | OPRM1OPRD1DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL10914999 | 0.80 | OPRM1 (0.47) | ADRA1DADRA1AADRA1BOPRM1OPRD1 | |
| SCHEMBL10966715 | 0.79 | LMNA (0.54) | ADRA1DADRA1AADRA1BOPRM1OPRD1 | |
| SCHEMBL11288631 | 0.79 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BOPRM1OPRD1 | |
| SCHEMBL10916090 | 0.78 | DRD2 (0.50) | OPRM1OPRD1DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL10914753 | 0.76 | DRD2 (0.54) | ADRA1DADRA1AADRA1BOPRM1DRD2 | |
| Hydrochloric Acid SCHEMBL10974147 | 0.75 | OPRM1 (0.64) | ADRA1AOPRM1OPRD1KCNA3OPRK1 | |
| SCHEMBL10922313 | 0.75 | MEN1 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064707-B1 | 4-(4-PHENYL-1-PIPERIDINYL)METHYL-5-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-07-23 | — | — | EP | disclosed |
| US-4329471-A | CARDIOTONICS, HYPOTENSIVE AGENTS, AND ANTITHROMBOTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-05-11 | — | — | US | disclosed |