Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11297396 | 0.91 | HRH1 (0.46) | DPP4HRH1CHRM1CHRM3TP53 | |
| SCHEMBL11374085 | 0.89 | MMP2 (0.40) | DPP4HRH1CHRM1CHRM3TP53 | |
| SCHEMBL22445659 | 0.86 | DPP4 (0.47) | DPP4TP53MAPK1RAB9AALDH1A1 | |
| SCHEMBL11334274 | 0.81 | CHRM1 (0.40) | CHRM1CHRM3RAB9AALDH1A1HSD17B10 | |
| SCHEMBL31376578 | 0.80 | ALDH1A1 (0.43) | DPP4CHRM1CHRM3MAPK1ALDH1A1 | |
| SCHEMBL7012979 | 0.80 | ALDH1A1 (0.43) | DPP4CHRM1CHRM3MAPK1ALDH1A1 | |
| SCHEMBL7012982 | 0.80 | ALDH1A1 (0.43) | DPP4CHRM1CHRM3MAPK1ALDH1A1 | |
| SCHEMBL4449616 | 0.80 | CHRM1 (0.39) | DPP4CHRM1CHRM3ALDH1A1HSD17B10 | |
| SCHEMBL11489696 | 0.78 | DPP4 (0.42) | DPP4HRH1TP53MAPK1RAB9A | |
| SCHEMBL11249397 | 0.77 | HTR7 (0.46) | HRH1CHRM1CHRM3ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015776-B1 | 1,1'-BIPHENYL-2-YL ALKYLAMINE DERIVATIVES, THEIR PRODUCTION AND CARDIOVASCULAR PREPARATIONS CONTAINING SAME | ELI LILLY AND COMPANY (US) | 1982-06-30 | — | — | EP | disclosed |
| US-4277471-A | 1,1-Biphenyl-2-yl alkylamines, formulations and antiarrhythmic treatment | ELI LILLY AND COMPANY (US) | 1981-07-07 | — | — | US | disclosed |
| EP-0015776-A1 | 1,1'-Biphenyl-2-yl alkylamine derivatives, their production and cardiovascular preparations containing same | ELI LILLY AND COMPANY (US) | 1980-09-17 | — | — | EP | disclosed |