SCHEMBL11289576

SCHEMBL11289576

CC1(C)CC(O[Si](OC2CC(C)(C)NC(C)(C)C2)(c2ccccc2)c2ccccc2)CC(C)(C)N1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.50
ALOX15 P16050 2/20 0.41
KMT2A Q03164 2/20 0.41
ALDH1A1 P00352 2/20 0.41
LMNA P02545 2/20 0.41
MEN1 O00255 1/20 0.41
MAPT P10636 1/20 0.41
PKM P14618 1/20 0.41
ALOX12 P18054 1/20 0.41
RAD52 P43351 1/20 0.41
GFER P55789 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
KDM1A O60341 3/20 0.40
POLB P06746 1/20 0.37
EZH2 Q15910 3/20 0.37
TSHR P16473 1/20 0.37
HTT P42858 1/20 0.35
USP2 O75604 1/20 0.35
SLC2A1 P11166 1/20 0.35
KDM4E B2RXH2 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL315320 0.86 GAA (0.50) GAAALOX15KMT2AALDH1A1LMNA
SCHEMBL11523500 0.86 GAA (0.50) GAAALOX15KMT2AALDH1A1LMNA
SCHEMBL20641825 0.85 GAA (0.47) GAAALOX15KMT2AALDH1A1LMNA
SCHEMBL11525970 0.85 GAA (0.49) GAAALOX15KMT2AALDH1A1LMNA
SCHEMBL11529859 0.85 GAA (0.49) GAAALOX15KMT2AALDH1A1LMNA
SCHEMBL11525444 0.78 LMNA (0.36) GAAKMT2ALMNAKDM1ATSHR
SCHEMBL6662214 0.75 GAA (0.42) GAAALOX15KMT2AALDH1A1LMNA
SCHEMBL451934 0.73 GAA (0.54) GAAALOX15KMT2AALDH1A1LMNA
SCHEMBL11527304 0.72 KMT2A (0.42) GAAKMT2AALDH1A1LMNAMEN1
SCHEMBL11527520 0.72 OPRK1 (0.38) GAAKMT2AMEN1MAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4177186-A 4-SILOXY-DERIVATIVES OF STERICALLY HINDERED PIPERIDINES CIBA-GEIGY CORPORATION (US) 1979-12-04 US claimed
EP-0007468-B1 COMPOSITIONS PHOTODURCISSABLES CIBA-GEIGY AG (CH) 1982-04-07 EP disclosed
US-4284485-A STABILIZED WITH A POLYALKYLPIPERIDINE DERIVATIVE CIBA-GEIGY CORPORATION (US) 1981-08-18 US disclosed
US-4279720-A PHENYLGLYOXYLATE PHOTOINITIATOR WITH POLYALKYLPIPERIDINE STABILIZER CIBA-GEIGY CORPORATION (US) 1981-07-21 US disclosed
EP-0007059-B1 PHOTOCURABLE COMPOSITIONS CIBA-GEIGY AG (CH) 1981-04-15 EP disclosed
US-4202816-A ENOL-PIPERIDINE METAL COMPLEXES CIBA-GEIGY CORPORATION (US) 1980-05-13 US disclosed
EP-0007059-A1 Photocurable compositions CIBA-GEIGY AG (CH) 1980-01-23 EP disclosed
US-4177186-A 4-SILOXY-DERIVATIVES OF STERICALLY HINDERED PIPERIDINES CIBA-GEIGY CORPORATION (US) 1979-12-04 US disclosed