Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3291605 | 0.91 | POLB (0.51) | POLBTDP1MAPK1ALDH1A1RAB9A | |
| SCHEMBL10487643 | 0.83 | POLB (0.53) | POLBTDP1ALDH1A1RAB9AMEN1 | |
| SCHEMBL6060993 | 0.78 | ALDH1A1 (0.49) | POLBTDP1MAPK1ALDH1A1RAB9A | |
| SCHEMBL7714032 | 0.76 | ALDH1A1 (0.56) | ALDH1A1NAMPTNPC1MAPTKDM4E | |
| SCHEMBL10107952 | 0.76 | ALDH1A1 (0.52) | POLBMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL4855763 | 0.76 | ALDH1A1 (0.51) | TDP1ALDH1A1KMT2ANAMPTNPC1 | |
| SCHEMBL10108013 | 0.76 | ALDH1A1 (0.70) | ALDH1A1NAMPTMAPTSMN1; SMN2GAA | |
| SCHEMBL7788835 | 0.75 | ABL1 (0.49) | POLBMAPK1ALDH1A1RAB9AMEN1 | |
| SCHEMBL23262028 | 0.75 | CYP4Z1 (0.49) | TDP1MAPK1ALDH1A1MAPTBRD4 | |
| SCHEMBL6829473 | 0.75 | ALDH1A1 (0.51) | POLBTDP1MAPK1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0006217-B1 | SUBSTITUTED AMINO ACIDS, THEIR USE AND PREPARATION, AND COMPOSITIONS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1982-03-31 | — | — | EP | disclosed |
| US-4260684-A | Stereoselective resolution of phenylglycine derivatives and 4-hydroxyphenylglycine derivatives with enzyme resins | BAYER AKTIENGESELLSCHAFT (DE) | 1981-04-07 | — | — | US | disclosed |
| US-4243678-A | GASTROINTESTINAL DISORDERS, LIVER DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-01-06 | — | — | US | disclosed |
| EP-0006217-A1 | Substituted amino acids, their use and preparation, and compositions containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1980-01-09 | — | — | EP | disclosed |