Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11422481 | 1.00 | ALDH1A1 (0.48) | ALDH1A1LMNAHSD17B10GLO1NPSR1 | |
| SCHEMBL6898586 | 0.83 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10GLO1NPSR1 | |
| SCHEMBL11416591 | 0.83 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10GLO1NPSR1 | |
| SCHEMBL11416602 | 0.83 | ALDH1A1 (0.44) | ALDH1A1LMNAHSD17B10GLO1NPSR1 | |
| SCHEMBL28221030 | 0.83 | THRB (0.46) | ALDH1A1LMNAHSD17B10GLO1NPSR1 | |
| SCHEMBL7101348 | 0.81 | NPSR1 (0.48) | ALDH1A1LMNAHSD17B10GLO1NPSR1 | |
| SCHEMBL7101351 | 0.81 | NPSR1 (0.48) | ALDH1A1LMNAHSD17B10GLO1NPSR1 | |
| SCHEMBL13275367 | 0.80 | GLO1 (0.41) | ALDH1A1LMNAHSD17B10GLO1NPSR1 | |
| SCHEMBL11418961 | 0.80 | ALDH1A1 (0.41) | ALDH1A1LMNAHSD17B10GLO1NPSR1 | |
| SCHEMBL13275368 | 0.80 | GLO1 (0.41) | ALDH1A1LMNAHSD17B10GLO1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174500-A1 | PRODRUGS OF ALPHA-KETOGLUTARATE, ALPHA-KETOBUTYRATE, ALPHA-KETOISOVALERATE, AND ALPHA-KETOISOHEXANOATE, AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-06-08 | — | — | US | disclosed |
| US-20230174500-A1 | PRODRUGS OF ALPHA-KETOGLUTARATE, ALPHA-KETOBUTYRATE, ALPHA-KETOISOVALERATE, AND ALPHA-KETOISOHEXANOATE, AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-06-08 | — | — | US | disclosed |
| US-11524948-B2 | Prodrugs of alpha-ketoglutarate, alpha-ketobutyrate, alpha-ketoisovalerate, and alpha-ketoisohexanoate, and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-12-13 | — | — | US | disclosed |
| US-20200325113-A1 | PRODRUGS OF ALPHA-KETOGLUTARATE, ALPHA-KETOBUTYRATE, ALPHA-KETOISOVALERATE, AND ALPHA-KETOISOHEXANOATE, AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-10-15 | — | — | US | disclosed |
| WO-2020081836-A1 | PRODRUGS OF ALPHA-KETOGLUTARATE, ALPHA-KETOBUTYRATE, ALPHA-KETOISOVALERATE, AND ALPHA-KETOISOHEXANOATE, AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-04-23 | — | — | WO | disclosed |
| EP-0043088-A1 | Process for the production of alkyl esters of acetoactic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-01-06 | — | — | EP | disclosed |
| US-4194051-A | Asymmetric catalysis | MONSANTO COMPANY (US) | 1980-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11524948-B2 | Prodrugs of alpha-ketoglutarate, alpha-ketobutyrate, alpha-ketoisovalerate, and alpha-ketoisohexanoate, and uses thereof | HOGA1, TKT, BCKDK | ALDH1A1 230/4885LMNA 1516/4885HSD17B10 127/4885 |
| US-20230174500-A1 | PRODRUGS OF ALPHA-KETOGLUTARATE, ALPHA-KETOBUTYRATE, ALPHA-KETOISOVALERATE, AND ALPHA-KETOISOHEXANOATE, AND USES THEREOF | HOGA1, ABAT, GLO1 | ALDH1A1 429/4885LMNA 2223/4885HSD17B10 70/4885 |
| US-20200325113-A1 | PRODRUGS OF ALPHA-KETOGLUTARATE, ALPHA-KETOBUTYRATE, ALPHA-KETOISOVALERATE, AND ALPHA-KETOISOHEXANOATE, AND USES THEREOF | HOGA1, ABAT, GLO1 | ALDH1A1 429/4885LMNA 2223/4885HSD17B10 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.