Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL11295494 | 0.82 | MTNR1A (0.36) | MTNR1AMTNR1BPDK2OPRM1OPRL1 | |
| SCHEMBL11503333 | 0.76 | MTNR1A (0.33) | MTNR1AMTNR1BHDAC4 | |
| SCHEMBL11291104 | 0.73 | SMN1; SMN2 (0.42) | MTNR1AMTNR1BHDAC4 | |
| SCHEMBL11288858 | 0.71 | SLC6A4 (0.34) | TSHR | |
| SCHEMBL31452460 | 0.71 | SLC6A4 (0.34) | TSHR | |
| SCHEMBL11544999 | 0.71 | AKR1C1 (0.37) | APOBEC3AAPOBEC3GPDK2HDAC4TSHR | |
| SCHEMBL11294472 | 0.70 | HDAC4 (0.35) | PDK2HDAC4 | |
| SCHEMBL11349725 | 0.70 | ADRB2 (0.41) | TSHR | |
| SCHEMBL11548754 | 0.70 | HDAC4 (0.35) | PDK2HDAC4 | |
| SCHEMBL11297051 | 0.70 | POLB (0.39) | OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000825-B1 | GEMINALLY DISUBSTITUTED INDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Kabi AB (SE) | 1982-04-14 | — | — | EP | disclosed |
| US-4218472-A | USED AS DECONGESANT, HYPOTENSIVE AGENT, VASOCONSTRICTOR, ANTI-RESERPINE AGENT, TREATING INCONTINENCE | AB KABI (SE) | 1980-08-19 | — | — | US | disclosed |
| EP-0000825-A1 | Geminally disubstituted indene derivatives, processes for their preparation and pharmaceutical compositions containing them | Kabi AB (SE) | 1979-02-21 | — | — | EP | disclosed |