Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 14/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.52 |
| ▸ | CTSA | P10619 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364607 | 0.93 | SCN9A (0.64) | MAPTSCN9A | |
| SCHEMBL483444 | 0.86 | MAPT (0.56) | MAPTNPC1CASP3RAB9ASMN1; SMN2 | |
| SCHEMBL1260197 | 0.85 | ALDH1A1 (0.52) | RAB9ASMN1; SMN2 | |
| SCHEMBL25002897 | 0.84 | MAPT (0.58) | MAPTNPC1RAB9ASMN1; SMN2SLC6A4 | |
| SCHEMBL25002929 | 0.84 | ADORA3 (0.52) | MAPTNPC1RAB9ASMN1; SMN2SCN9A | |
| SCHEMBL11158237 | 0.84 | SCN10A (0.45) | MAPTNPC1CASP3RAB9ASMN1; SMN2 | |
| SCHEMBL23037197 | 0.83 | MAPT (0.54) | MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29595815 | 0.83 | MAPT (0.54) | MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28213723 | 0.83 | IRAK4 (0.48) | MAPTNPC1RAB9ASMN1; SMN2SCN9A | |
| SCHEMBL4591255 | 0.82 | SCN10A (0.65) | MAPTSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098387-A1 | 6, 7-RING-FUSED TRIAZOLO [4, 3 - B] PYRIDAZINE DERIVATIVES AS PIM INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-07-26 | — | — | WO | disclosed |
| WO-2012098387-A1 | 6, 7-RING-FUSED TRIAZOLO [4, 3 - B] PYRIDAZINE DERIVATIVES AS PIM INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-07-26 | — | — | WO | disclosed |