Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 4/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | CTSA | P10619 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483444 | 0.86 | MAPT (0.56) | MAPTSMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL1260197 | 0.85 | ALDH1A1 (0.52) | SMN1; SMN2RAB9ACNR2ALDH1A1KDM4E | |
| SCHEMBL4592907 | 0.85 | CNR2 (0.65) | CNR2SLC6A3CNR1 | |
| SCHEMBL18439000 | 0.84 | CNR2 (0.51) | MAPTSMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL11158237 | 0.84 | SCN10A (0.45) | MAPTSMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL11297183 | 0.84 | MAPT (0.61) | MAPTSMN1; SMN2NPC1RAB9ASLC6A4 | |
| SCHEMBL25002929 | 0.84 | ADORA3 (0.52) | MAPTSMN1; SMN2NPC1RAB9ACTSA | |
| SCHEMBL4436292 | 0.84 | NOTUM (0.57) | MAPTSMN1; SMN2NPC1RAB9ACNR2 | |
| SCHEMBL23037197 | 0.83 | MAPT (0.54) | MAPTSMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL29595815 | 0.83 | MAPT (0.54) | MAPTSMN1; SMN2NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010192-A1 | N-ACYLHYDRAZONE COMPOUNDS CAPABLE OF INHIBITING NAV1.7 AND/OR NAV1.8, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-02-09 | — | — | WO | disclosed |