Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL483444 | 0.86 | MAPT (0.56) | SCN10AMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1260197 | 0.85 | ALDH1A1 (0.52) | RAB9ASMN1; SMN2GAAFAAHCES1 | |
| SCHEMBL6439408 | 0.85 | MAPT (0.55) | MAPTNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL25002897 | 0.84 | MAPT (0.58) | SCN10AMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11297183 | 0.84 | MAPT (0.61) | MAPTNPC1RAB9ASMN1; SMN2SCN9A | |
| SCHEMBL25002929 | 0.84 | ADORA3 (0.52) | SCN10AMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23037197 | 0.83 | MAPT (0.54) | MAPTNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL29595815 | 0.83 | MAPT (0.54) | MAPTNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL28213723 | 0.83 | IRAK4 (0.48) | MAPTNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL3711274 | 0.81 | MCL1 (0.55) | MAPTSMN1; SMN2CYP1A2GAARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034349-B1 | NOVEL PYRIDINECARBOXAMIDE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, THE USE OF SAID DERIVATIVES AND A PHARMACEUTICAL COMPOSITION CONTAINING SAME | Tanabe Seiyaku Co., Ltd. (JP) | 1983-12-14 | — | — | EP | disclosed |
| US-4332809-A | ANTIALLERGENS | TANABE SEIYAKU CO., LTD. (JP) | 1982-06-01 | — | — | US | disclosed |
| EP-0034349-A2 | Novel pyridinecarboxamide derivatives, a process for the preparation thereof, the use of said derivatives and a pharmaceutical composition containing same | Tanabe Seiyaku Co., Ltd. (JP) | 1981-08-26 | — | — | EP | disclosed |