Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11300678 | 0.81 | AR (0.44) | NR3C1 | |
| SCHEMBL11306515 | 0.77 | ADRB1 (0.44) | HTR6ADRB1HTR7HTR1ASLC6A2 | |
| SCHEMBL15754665 | 0.75 | ACHE (0.47) | — | |
| SCHEMBL11300280 | 0.75 | OPRL1 (0.47) | HTR6ADRB1HTR7HTR1ASLC6A2 | |
| SCHEMBL8705117 | 0.70 | HTR6 (0.49) | HTR6HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22542051 | 0.69 | ADRB1 (0.70) | HTR6ADRB1HTR7HTR1A | |
| SCHEMBL11296865 | 0.68 | NR3C1 (0.49) | NR3C1 | |
| Hydrochloric Acid SCHEMBL27907732 | 0.68 | ADRB1 (0.68) | ADRB1HTR7HTR1A | |
| SCHEMBL4931607 | 0.68 | HTR6 (1.00) | HTR6ADRB1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL20884921 | 0.67 | HTR2C (0.54) | HTR6ADRB1HTR7HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665724-A1 | BICYCLIC INHIBITORS OF ALK | AbbVie Inc. (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012097682-A1 | BICYCLIC INHIBITORS OF ALK | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | WO | disclosed |