Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11067487 | 0.85 | SMN1; SMN2 (0.41) | RAB9ASMN1; SMN2NPC1MAPTPOLB | |
| SCHEMBL11410033 | 0.79 | TSHR (0.57) | RAB9ASMN1; SMN2NPC1MAPTPOLB | |
| SCHEMBL11555935 | 0.79 | LMNA (0.45) | RAB9ATSHRMAPK1 | |
| SCHEMBL11071275 | 0.78 | ALDH1A1 (0.43) | MAPTCYP2C19TSHRMAPK1MEN1 | |
| SCHEMBL3144570 | 0.76 | TDP1 (0.49) | RAB9ANPC1MAPTCA12CA1 | |
| SCHEMBL11497010 | 0.76 | RAB9A (0.44) | RAB9ASMN1; SMN2NPC1MAPTPOLB | |
| SCHEMBL11257181 | 0.75 | LMNA (0.37) | AURKANTRK1RAB9APOLBMAPK1 | |
| SCHEMBL8249383 | 0.75 | MAPT (0.43) | RAB9ANPC1MAPTCA12CA1 | |
| SCHEMBL3826655 | 0.75 | MAPT (0.47) | SMN1; SMN2MAPTCYP2C19CA12CA1 | |
| SCHEMBL2036336 | 0.74 | NPC1 (0.54) | RAB9ASMN1; SMN2NPC1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4281019-A | 4-[(Unsaturated or cyclopropylated alkyl)amino]phenyl compounds useful as hypolipidemic and antiatherosclerotic agents | AMERICAN CYANAMID COMPANY (US) | 1981-07-28 | — | — | US | disclosed |
| EP-0003663-A2 | Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1979-08-22 | — | — | EP | disclosed |