Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 4/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275580 | 0.91 | KCNH2 (0.60) | KCNH2ABCB1HTR1AHTR7DRD2 | |
| SCHEMBL11276199 | 0.87 | KCNH2 (0.58) | KCNH2ABCB1HTR1AHTR7DRD2 | |
| SCHEMBL11300075 | 0.85 | KCNH2 (0.62) | KCNH2ABCB1HTR1AHTR7DRD2 | |
| SCHEMBL11275227 | 0.82 | KCNH2 (0.60) | KCNH2ABCB1HTR7SLC6A2SLC6A4 | |
| SCHEMBL11278975 | 0.81 | ADRA1D (0.68) | KCNH2HTR7SLC6A2SLC6A4DRD2 | |
| SCHEMBL11283459 | 0.80 | KCNH2 (0.60) | KCNH2ABCB1SIGMAR1 | |
| SCHEMBL11276248 | 0.80 | KCNH2 (0.57) | KCNH2ABCB1HTR1AHTR7SLC6A2 | |
| SCHEMBL11270171 | 0.80 | KCNH2 (0.57) | KCNH2ABCB1HTR1AHTR7SLC6A2 | |
| SCHEMBL11270602 | 0.80 | HTR1A (0.54) | HTR1AHTR7DRD2HTR2ASIGMAR1 | |
| SCHEMBL11270870 | 0.78 | HTR1A (0.59) | KCNH2HTR1ADRD2HTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |