Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11369641 | 0.86 | DRD2 (0.43) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| Bromide SCHEMBL11337378 | 0.85 | DRD2 (0.43) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| SCHEMBL11391165 | 0.83 | DRD2 (0.40) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| Hydrochloric Acid SCHEMBL11326699 | 0.82 | DRD2 (0.39) | DRD2DRD4SLC18A3SIGMAR1HTR1A | |
| SCHEMBL11399556 | 0.80 | DRD2 (0.44) | DRD2DRD4SIGMAR1HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL11331661 | 0.79 | DRD2 (0.44) | DRD2DRD4SIGMAR1HTR1AHTR2A | |
| Oxalic Acid SCHEMBL11326300 | 0.78 | AGTR2 (0.40) | SIGMAR1TMEM97 | |
| SCHEMBL11424749 | 0.78 | TMEM97 (0.37) | SIGMAR1TMEM97 | |
| SCHEMBL11321439 | 0.77 | SIGMAR1 (0.44) | SIGMAR1TMEM97 | |
| SCHEMBL11377955 | 0.76 | DRD2 (0.38) | DRD2DRD4SLC18A3SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4301292-A | 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol | HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) | 1981-11-17 | — | — | US | disclosed |
| US-4292243-A | 3\"-Phenyldispiro[1,3-dioxolane-2,4'-cyclohexane-1',1\"-(3\"H)-isobenzofuran] | HOECHST ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-09-29 | — | — | US | disclosed |
| US-4290958-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-09-22 | — | — | US | disclosed |
| US-4288623-A | 1-Aryl-4-amino-cyclohexan-1-ols | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1981-09-08 | — | — | US | disclosed |
| EP-0027522-A1 | Spiro(cyclohexane-1,1'(3'H)-isobenzofuran)s, processes and intermediates for their preparation and pharmaceutical compositions containing them | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-04-29 | — | — | EP | disclosed |
| US-4263317-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-04-21 | — | — | US | disclosed |