Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10890710 | 0.83 | MEN1 (0.50) | MEN1CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL20676951 | 0.78 | MEN1 (0.35) | MEN1CYP1A2CYP3A4CYP2D6TSHR | |
| Glycolic Acid SCHEMBL11329922 | 0.73 | SLC6A12 (0.38) | MEN1CYP1A2CYP3A4CYP2D6TSHR | |
| Glycolic Acid SCHEMBL10887541 | 0.73 | SLC6A12 (0.38) | MEN1CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL24268905 | 0.73 | — | — | |
| Sulfuric Acid SCHEMBL28248625 | 0.70 | — | — | |
| Sulfuric Acid SCHEMBL15211051 | 0.68 | CA1 (0.43) | KDM4EMAPTHPGDCA5ACA5B | |
| Sulfuric Acid SCHEMBL9769220 | 0.67 | THRB (0.59) | MEN1TSHRKMT2AKDM4EMAPT | |
| Sulfuric Acid SCHEMBL9494057 | 0.67 | THRB (0.59) | MEN1TSHRKMT2AKDM4EMAPT | |
| SCHEMBL8308075 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4359425-A | OF A DIAMONO FUSED SATURATED HYDROCARBON RING, HAVING ANTITUMOR ACTIVITY | SHIONOGI & CO., LTD. (JP) | 1982-11-16 | — | — | US | claimed |
| US-4359425-A | OF A DIAMONO FUSED SATURATED HYDROCARBON RING, HAVING ANTITUMOR ACTIVITY | SHIONOGI & CO., LTD. (JP) | 1982-11-16 | — | — | US | disclosed |