SCHEMBL1132986

SCHEMBL1132986

CC1=C(Cc2ccccc2CC2=C(C)C(=O)NC2=O)C(=O)NC1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 2/20 0.38
MEN1 O00255 3/20 0.34
LMNA P02545 3/20 0.34
MAPT P10636 3/20 0.34
KMT2A Q03164 3/20 0.34
CASP3 P42574 1/20 0.33
CASP2 P42575 1/20 0.33
CASP7 P55210 1/20 0.33
CASP6 P55212 1/20 0.33
CASP8 Q14790 1/20 0.33
AR P10275 2/20 0.33
ELANE P08246 1/20 0.32
DAO P14920 1/20 0.32
MAPK1 P28482 2/20 0.32
SMN1; SMN2 Q16637 4/20 0.32
KDM4E B2RXH2 3/20 0.32
ALDH1A1 P00352 3/20 0.32
TDP1 Q9NUW8 2/20 0.32
PRKD3 O94806 2/20 0.32
PRKCG P05129 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1133697 0.89 ELANE (0.33) GSK3BELANEDAO
SCHEMBL1133477 0.83 DAO (0.34) ARELANEDAOKDM4EALDH1A1
SCHEMBL3672110 0.82 GSK3B (0.37) GSK3BMEN1LMNAMAPTKMT2A
SCHEMBL907302 0.82 KMT2A (0.41) GSK3BMEN1MAPTKMT2AELANE
SCHEMBL1133158 0.79 DAO (0.34) GSK3BMEN1LMNAMAPTKMT2A
SCHEMBL168683 0.77 DAO (0.38) MEN1KMT2ADAOSMN1; SMN2KDM4E
SCHEMBL3676317 0.76 DAO (0.31) GSK3BDAO
SCHEMBL1133470 0.75 TGM2 (0.33) LMNADAOHPGD
SCHEMBL21711979 0.75 HSD17B10 (0.32) SMN1; SMN2KDM4EALDH1A1HPGD
SCHEMBL1133219 0.75 ESR1 (0.34) LMNADAOHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2287015-A2 Pneumatic tire Bridgestone Corporation (JP) 2011-02-23 EP claimed
US-20060272760-A1 Pneumatic tire BRIDGESTONE CORPORATION 2006-12-07 US claimed
EP-1297974-A1 PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2003-04-02 EP claimed
US-20030015272-A1 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-23 US claimed
WO-2023095850-A1 STEEL CORD-RUBBER COMPOSITE, MANUFACTURING METHOD FOR STEEL CORD-RUBBER COMPOSITE, AND TIRE 株式会社ブリヂストン 2023-06-01 WO disclosed
CN-111094428-B Rubber composition 住友化学株式会社 2022-07-15 CN disclosed
CN-113993719-A Trisulfide compound 住友化学株式会社 2022-01-28 CN disclosed
CN-113490607-A Vulcanized rubber composition 住友化学株式会社 2021-10-08 CN disclosed
CN-111094428-A Rubber composition 住友化学株式会社 2020-05-01 CN disclosed
EP-2289710-B1 Pneumatic tire BRIDGESTONE CORP (JP) 2018-11-07 EP disclosed
US-9617404-B2 Rubber composition, conveyor belt rubber composition, conveyor belt, and belt conveyor device BRIDGESTONE CORPORATION (JP) 2017-04-11 US disclosed
EP-1297974-B1 PNEUMATIC TIRE BRIDGESTONE CORP (JP) 2017-03-15 EP disclosed
US-20100175805-A1 RUBBER COMPOSITION FOR COVERING TEXTILE CORD AND TIRE EMPLOYING THE SAME SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2010-07-15 US disclosed
US-20090151844-A1 Rubber Composition for Bead Apex and Tire Having Bead Apex Prepared Using Same SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2009-06-18 US disclosed
EP-2009049-A1 RUBBER COMPOSITION FOR BEAD APEX AND TIRE WITH BEAD APEX UTILIZING THE SAME Sumitomo Rubber Industries, Ltd. (JP) 2008-12-31 EP disclosed
US-20060272760-A1 Pneumatic tire BRIDGESTONE CORPORATION 2006-12-07 US disclosed
US-20030088023-A1 Containing an alkylenebis(dithio-nitrogen cap) compound, a citraconimide compound, or an acrylate compound; suitable particularly for a reinforcing rubber for tire sidewall portions and for a tire bead filler rubber. BRIDGESTONE CORPORATION (JP) 2003-05-08 US disclosed
EP-1297974-A1 PNEUMATIC TIRE BRIDGESTONE CORPORATION (JP) 2003-04-02 EP disclosed
US-20030015272-A1 Pneumatic tire BRIDGESTONE CORPORATION (JP) 2003-01-23 US disclosed
EP-1197518-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE MADE WITH THE SAME BRIDGESTONE CORPORATION (JP) 2002-04-17 EP disclosed