Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 known ✓ | P21453 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 2/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11331992 | 1.00 | ALDH1A1 (0.45) | ALDH1A1HCAR2S1PR1S1PR3FDPS | |
| SCHEMBL11336312 | 0.90 | ALDH1A1 (0.53) | ALDH1A1FDPSSMPD1 | |
| Acetic Acid SCHEMBL11336531 | 0.89 | ALDH1A1 (0.49) | ALDH1A1FDPSSMPD1 | |
| SCHEMBL11338556 | 0.89 | ALDH1A1 (0.52) | ALDH1A1FDPSSMPD1 | |
| Succinic Acid SCHEMBL11336383 | 0.86 | ALDH1A1 (0.50) | ALDH1A1 | |
| SCHEMBL11340911 | 0.85 | ALDH1A1 (0.55) | ALDH1A1FDPSSMPD1 | |
| SCHEMBL11341101 | 0.84 | ALDH1A1 (0.47) | ALDH1A1FDPSSMPD1 | |
| Phosphoric Acid SCHEMBL11333132 | 0.84 | FDPS (0.49) | ALDH1A1FDPSSMPD1 | |
| Oxalic Acid SCHEMBL11341238 | 0.83 | ALDH1A1 (0.50) | ALDH1A1FDPSSMPD1 | |
| Cadaverine Tartrate SCHEMBL11346970 | 0.83 | ALDH1A1 (0.44) | ALDH1A1FDPSSMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4277498-A | Amides | BURROUGHS WELLCOME CO. (US) | 1981-07-07 | — | — | US | disclosed |