Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11456891 | 0.96 | MEN1 (0.42) | MEN1KMT2ASIGMAR1OPRM1OPRD1 | |
| SCHEMBL11347007 | 0.88 | SIGMAR1 (0.43) | MEN1KMT2ASIGMAR1OPRM1OPRD1 | |
| SCHEMBL11331580 | 0.87 | SIGMAR1 (0.41) | MEN1KMT2ASIGMAR1CHRM2CHRM3 | |
| SCHEMBL11341610 | 0.86 | KDM4E (0.50) | MEN1KMT2ASIGMAR1OPRM1OPRD1 | |
| SCHEMBL11481378 | 0.85 | MEN1 (0.39) | MEN1KMT2ASIGMAR1CHRM2CHRM3 | |
| SCHEMBL11344631 | 0.84 | MEN1 (0.36) | MEN1KMT2ASIGMAR1POLBCHRM2 | |
| SCHEMBL11447020 | 0.83 | OPRD1 (0.42) | MEN1KMT2ASIGMAR1OPRM1OPRD1 | |
| SCHEMBL11446906 | 0.83 | SIGMAR1 (0.39) | MEN1KMT2ASIGMAR1CHRM2CHRM3 | |
| SCHEMBL11437822 | 0.82 | MEN1 (0.42) | MEN1KMT2ASIGMAR1OPRM1OPRD1 | |
| SCHEMBL11447557 | 0.82 | OPRM1 (0.50) | MEN1KMT2ASIGMAR1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156014-A | N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | claimed |
| US-RE30837-E | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-12-29 | — | — | US | disclosed |
| US-4199589-A | N-(2-Aminocycloheptyl)acylanilides and methods to treat depression | SZMUSZKOVICZ JACOB (US) | 1980-04-22 | — | — | US | disclosed |
| US-4172898-A | N-(2-aminocycloheptyl)acylanilides | THE UPJOHN COMPANY (US) | 1979-10-30 | — | — | US | disclosed |
| US-4169156-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-09-25 | — | — | US | disclosed |
| US-4159339-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-4156014-A | N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | disclosed |