Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 2/20 | 0.47 |
| ▸ | FGF1 | P05230 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.47 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.47 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | CD40 | P25942 | 2/20 | 0.42 |
| ▸ | CD40LG | P29965 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10908400 | 0.93 | DEGS1 (0.42) | TIMP3FGF1PRMT1PRMT3EP300 | |
| SCHEMBL11338609 | 0.90 | PRMT1 (0.49) | TIMP3FGF1PRMT1PRMT3EP300 | |
| SCHEMBL11350543 | 0.88 | KMT2A (0.52) | TIMP3PRMT1SIRT1POLBRAB9A | |
| SCHEMBL11427755 | 0.86 | CASP6 (0.48) | PRMT1POLBRAB9AKMT2A | |
| SCHEMBL10907652 | 0.83 | PRMT1 (0.42) | TIMP3FGF1PRMT1PRMT3EP300 | |
| SCHEMBL11341867 | 0.83 | DHODH (0.44) | TIMP3PRMT1SIRT1POLBRAB9A | |
| SCHEMBL11344837 | 0.83 | PRMT1 (0.43) | PRMT1PRMT3EP300PRMT6ENPP2 | |
| SCHEMBL11347286 | 0.82 | TIMP3 (0.49) | TIMP3FGF1PRMT1PRMT3EP300 | |
| SCHEMBL11437915 | 0.82 | CD40 (0.54) | PRMT1POLBCD40CD40LGRAB9A | |
| SCHEMBL10823709 | 0.82 | LMNA (0.52) | PRMT1PRMT3EP300PRMT6ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0013784-A1 | C-Substituted naphthalenemonosulfonic ureides, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |