Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 3/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.47 |
| ▸ | MPL | P40238 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.45 |
| ▸ | FGF1 | P05230 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | CD40 | P25942 | 1/20 | 0.43 |
| ▸ | CD40LG | P29965 | 1/20 | 0.43 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10907712 | 0.92 | MPL (0.46) | TIMP3MPLPRMT1CTDSP1CASP6 | |
| SCHEMBL11339195 | 0.91 | TIMP3 (0.48) | TIMP3SIRT1MPLPRMT1FGF1 | |
| SCHEMBL11760881 | 0.90 | TIMP3 (0.52) | TIMP3SIRT1PRMT1FGF1CTDSP1 | |
| SCHEMBL11760843 | 0.90 | TIMP3 (0.49) | TIMP3SIRT1MPLPRMT1FGF1 | |
| SCHEMBL11339069 | 0.89 | KMT2A (0.53) | TIMP3SIRT1PRMT1HPSECA1 | |
| SCHEMBL11435352 | 0.87 | CASP6 (0.55) | MPLPRMT1CTDSP1CASP6CA1 | |
| SCHEMBL2679103 | 0.86 | MPL (0.51) | MPLPRMT1CASP6CA1CA2 | |
| SCHEMBL11341156 | 0.86 | TIMP3 (0.48) | TIMP3SIRT1PRMT1FGF1CTDSP1 | |
| SCHEMBL11338609 | 0.85 | PRMT1 (0.49) | TIMP3SIRT1PRMT1FGF1CD40 | |
| SCHEMBL10907905 | 0.84 | MPL (0.48) | TIMP3MPLCTDSP1CASP6CD40 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0013784-A1 | C-Substituted naphthalenemonosulfonic ureides, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |