Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 6/20 | 0.51 |
| ▸ | USP2 | O75604 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | RGS12 | O14924 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7709652 | 0.84 | TYMS (0.64) | TYMSUSP2KMT2AMEN1TDP1 | |
| SCHEMBL7709571 | 0.83 | TYMS (0.57) | TYMSUSP2KMT2AMEN1TDP1 | |
| SCHEMBL7709795 | 0.83 | HKDC1 (0.65) | TYMSUSP2KMT2AMEN1TDP1 | |
| SCHEMBL29836499 | 0.83 | TYMS (0.49) | TYMSUSP2KMT2AMEN1TDP1 | |
| SCHEMBL4077252 | 0.83 | TYMS (0.49) | TYMSUSP2KMT2AMEN1TDP1 | |
| SCHEMBL29556131 | 0.79 | USP2 (0.65) | TYMSUSP2KMT2AMEN1TDP1 | |
| SCHEMBL30516566 | 0.79 | USP2 (0.65) | TYMSUSP2KMT2AMEN1TDP1 | |
| SCHEMBL1025154 | 0.79 | USP2 (0.65) | TYMSUSP2KMT2AMEN1TDP1 | |
| SCHEMBL7703712 | 0.78 | TYMS (0.44) | TYMSUSP2KMT2AMEN1TDP1 | |
| SCHEMBL30608350 | 0.78 | TYMS (0.44) | TYMSHKDC1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110130557-A1 | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF | SYDDANSK UNIVERSITET (DK) | 2011-06-02 | — | — | US | disclosed |
| US-20110130557-A1 | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF | SYDDANSK UNIVERSITET (DK) | 2011-06-02 | — | — | US | disclosed |
| US-20110130557-A1 | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF | SYDDANSK UNIVERSITET (DK) | 2011-06-02 | — | — | US | disclosed |
| EP-2285820-A1 | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF | Syddansk Universitet (DK) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009135890-A1 | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF | SYDDANSK UNIVERSITET (DK) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009135890-A1 | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF | SYDDANSK UNIVERSITET (DK) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130557-A1 | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF | POLRMT, DDX1, DDX18 | TYMS 477/4885USP2 4681/4885KMT2A 2894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.