Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | USP2 | O75604 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133922 | 0.83 | TYMS (0.51) | TYMSKMT2AUSP2MEN1TDP1 | |
| SCHEMBL29836499 | 0.80 | TYMS (0.49) | TYMSKMT2AUSP2MEN1TDP1 | |
| SCHEMBL7709571 | 0.80 | TYMS (0.57) | TYMSKMT2AUSP2MEN1TDP1 | |
| SCHEMBL29556131 | 0.77 | USP2 (0.65) | TYMSKMT2AUSP2MEN1TDP1 | |
| SCHEMBL30516566 | 0.77 | USP2 (0.65) | TYMSKMT2AUSP2MEN1TDP1 | |
| SCHEMBL1025154 | 0.77 | USP2 (0.65) | TYMSKMT2AUSP2MEN1TDP1 | |
| SCHEMBL7703712 | 0.75 | TYMS (0.44) | TYMSKMT2AUSP2MEN1TDP1 | |
| SCHEMBL7709652 | 0.75 | TYMS (0.64) | TYMSKMT2AUSP2MEN1TDP1 | |
| SCHEMBL7709795 | 0.73 | HKDC1 (0.65) | TYMSKMT2AUSP2MEN1TDP1 | |
| SCHEMBL32869249 | 0.73 | TYMS (0.61) | TYMSKMT2AUSP2MEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626050-B1 | SULFUR-CONTAINING NAPHTHOYLIMIDE DERIVATIVES | UNIV EAST CHINA SCIENCE & TECH (CN) | 2009-12-02 | — | — | EP | disclosed |
| US-7541463-B2 | Sulfur-containing naphthalimide derivatives | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2009-06-02 | — | — | US | disclosed |
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | QIAN XUHONG | 2008-09-25 | — | — | US | disclosed |
| US-20060111367-A1 | Sulfur-containing naphthalimide derivatives | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCE (CN) | 2006-05-25 | — | — | US | disclosed |
| EP-1626050-A1 | SULFUR-CONTAINING NAPHTHOYLIMIDE DERIVATIVES | East China University of Science and Technology (CN) | 2006-02-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111367-A1 | Sulfur-containing naphthalimide derivatives | HCCS, SQOR, MKI67 | TYMS 631/4885KMT2A 1942/4885USP2 1327/4885 |
| US-20080234287-A1 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES | HCCS, SQOR, MKI67 | TYMS 631/4885KMT2A 1942/4885USP2 1327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.