Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 6/20 | 0.43 |
| ▸ | CTSS | P25774 | 6/20 | 0.43 |
| ▸ | CTSB | P07858 | 4/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18078251 | 0.84 | TRPM8 (0.52) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL4425151 | 0.84 | CTSB (0.53) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL10357140 | 0.84 | CTSB (0.53) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL4039888 | 0.84 | CTSB (0.53) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL20529553 | 0.84 | CTRB1 (0.48) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL2579674 | 0.83 | CYP3A4 (0.62) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL25933042 | 0.83 | CYP3A4 (0.48) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL18078250 | 0.83 | CTSL (0.51) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL7923871 | 0.83 | CTSL (0.51) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL11519751 | 0.83 | CYP3A4 (0.45) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001449-B1 | ANALOGUES OF SOMATOSTATIN, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PREPARATION | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-04-15 | — | — | EP | disclosed |
| EP-0001449-A2 | Analogues of somatostatin, pharmaceutical compositions containing them and their preparation | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-04-18 | — | — | EP | disclosed |
| US-4145337-A | SOMATOSTATINS, ANTISECRETORY | HOFFMANN-LA ROCHE INC. (US) | 1979-03-20 | — | — | US | disclosed |