Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000244 | 0.80 | HDAC1 (0.52) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL600144 | 0.78 | HDAC1 (0.60) | HDAC1HDAC6KDM4EKMT2ANAPRT | |
| Hydrochloric Acid SCHEMBL3891479 | 0.77 | HDAC1 (0.58) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL4491815 | 0.75 | HDAC1 (0.47) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL4491812 | 0.75 | HDAC1 (0.47) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL11342934 | 0.74 | GABRP (0.55) | HDAC1HDAC6KDM4ENAPRTSMN1; SMN2 | |
| SCHEMBL4400941 | 0.73 | HDAC1 (0.64) | HDAC1HDAC6KDM4EKMT2AKCNQ3 | |
| SCHEMBL181465 | 0.71 | HDAC1 (0.62) | HDAC1HDAC6KDM4ENAPRTMAPT | |
| SCHEMBL8192122 | 0.71 | HDAC1 (0.52) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL123712 | 0.71 | HDAC1 (0.52) | HDAC1HDAC6KDM4EADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001887-B1 | IMIDAZO(1,2-A)PYRIDINE COMPOUNDS, THEIR PREPARATION AND ANTHELMINTIC COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1981-10-21 | — | — | EP | disclosed |
| EP-0001887-A1 | Imidazo(1,2-a)pyridine compounds, their preparation and anthelmintic compositions containing them | MERCK & CO. INC. (US) | 1979-05-16 | — | — | EP | disclosed |
| US-4154835-A | Anthelmintic imidazo [1,2-a] pyridines | MERCK & CO., INC. (US) | 1979-05-15 | — | — | US | disclosed |