Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8192122 | 0.82 | HDAC1 (0.52) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL17033581 | 0.80 | HDAC1 (0.50) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL11625027 | 0.80 | HDAC1 (0.50) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL21450809 | 0.78 | HDAC1 (0.44) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL575041 | 0.77 | HDAC1 (0.62) | HDAC1HDAC6KDM4EKMT2AMAPT | |
| SCHEMBL31290288 | 0.77 | HDAC1 (0.62) | HDAC1HDAC6KDM4EKMT2AMAPT | |
| SCHEMBL20654542 | 0.77 | MAPT (0.32) | HDAC1HDAC6MAPT | |
| SCHEMBL2659565 | 0.77 | HDAC1 (0.52) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL21004360 | 0.77 | HDAC1 (0.61) | HDAC1HDAC6KDM4EADRA2AADRA2B | |
| SCHEMBL13864292 | 0.77 | HDAC1 (0.52) | HDAC1HDAC6KDM4EADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4374051-A | ISOPROPENYL- OR ACETYL SUBSTITUTED PYRIDINE DERIVATIVES; REGENERATION OF ESSENTIAL OILS; FLAVORS | FIRMENICH SA (CH) | 1983-02-15 | — | — | US | claimed |
| US-20250230137-A1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMACEUTICALS INC (US) | 2025-07-17 | — | — | US | disclosed |
| EP-3752497-B1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMACEUTICALS INC (US) | 2024-07-17 | — | — | EP | disclosed |
| US-20220331304-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | CONSTELLATION PHARMACEUTICALS, INC. | 2022-10-20 | — | — | US | disclosed |
| US-20210115008-A1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMACEUTICALS, INC. | 2021-04-22 | — | — | US | disclosed |
| EP-3752497-A1 | P300/CBP HAT INHIBITORS | Constellation Pharmaceuticals, Inc. (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2019161162-A1 | P300/CBP HAT INHIBITORS | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2019-08-22 | — | — | WO | disclosed |
| EP-2308509-B1 | INHIBITOR OF ANALGESIC TOLERANCE | KYOWA HAKKO KIRIN CO LTD (JP) | 2017-07-05 | — | — | EP | disclosed |
| EP-3002283-B1 | THIAZOLE DERIVATIVES | KYOWA HAKKO KIRIN CO LTD (JP) | 2017-06-14 | — | — | EP | disclosed |
| US-9255094-B2 | Pyrido[4,3-B]indoles and methods of use | MEDIVATION TECHNOLOGIES, INC. (US) | 2016-02-09 | — | — | US | disclosed |
| WO-2010127177-A1 | PYRIDO [4,3-B] INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2010-11-04 | — | — | WO | disclosed |
| EP-2217598-A1 | NEW TETRACYCLIC COMPOUNDS | Medivation Technologies, Inc. (US) | 2010-08-18 | — | — | EP | disclosed |
| EP-2189449-A1 | AMINOPYRAZOLE AMIDE DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2010-05-26 | — | — | EP | disclosed |
| US-20090239854-A1 | Tetracyclic compounds | MEDIVATION TECHNOLOGIES, INC. | 2009-09-24 | — | — | US | disclosed |
| WO-2009055828-A1 | NEW TETRACYCLIC COMPOUNDS | MEDIVATION TECHNOLOGIES, INC. (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2005103055-A1 | PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2005-11-03 | — | — | WO | disclosed |
| EP-0095269-B1 | RADIATION-SENSITIVE COMPOSITIONS OF POLYMERS CONTAINING A PI-METAL CARBONYL COMPLEX OF CONJUGATED POLYOLEFIN | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1988-02-24 | — | — | EP | disclosed |
| US-4503140-A | Radiation-sensitive compositions of polymers containing a π-metal carbonyl complex of conjugated polyolefin | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0095269-A2 | Radiation-sensitive compositions of polymers containing a pi-metal carbonyl complex of conjugated polyolefin | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1983-11-30 | — | — | EP | disclosed |
| US-4374051-A | ISOPROPENYL- OR ACETYL SUBSTITUTED PYRIDINE DERIVATIVES; REGENERATION OF ESSENTIAL OILS; FLAVORS | FIRMENICH SA (CH) | 1983-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115008-A1 | P300/CBP HAT INHIBITORS | EP300, HDAC1, KAT2A | HDAC1 2/4885HDAC6 28/4885KDM4E 807/4885 |
| US-20220331304-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | CLN6, ACHE, NLN | HDAC1 1289/4885HDAC6 112/4885KDM4E 4201/4885 |
| US-20250230137-A1 | P300/CBP HAT INHIBITORS | EP300, HDAC1, KAT2A | HDAC1 2/4885HDAC6 28/4885KDM4E 807/4885 |
| US-20090239854-A1 | Tetracyclic compounds | HTR2C, HTR3D, HTR5A | HDAC1 4146/4885HDAC6 2884/4885KDM4E 894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.