Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10585452 | 0.82 | ACHE (0.56) | CA2CA5AMAPTSMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4784885 | 0.81 | ACHE (0.55) | CA2CA5AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7284288 | 0.78 | MAPT (0.43) | CA2CA5AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8728410 | 0.77 | FFAR1 (0.44) | CA2CA5AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8982175 | 0.76 | OPRM1 (0.46) | CA2CA5AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6536539 | 0.74 | MAPT (0.53) | CA2CA5AMAPTSMN1; SMN2ALDH1A1 | |
| Acetic Acid SCHEMBL11345487 | 0.73 | HSD17B1 (0.42) | CA2OPRM1ACHEMEN1KMT2A | |
| SCHEMBL4843025 | 0.73 | EPHX2 (0.47) | CA2OPRM1ACHECA12CA9 | |
| SCHEMBL11342772 | 0.73 | CA2 (0.48) | CA2CA5AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9261533 | 0.73 | ALOX15 (0.56) | CA2CA5AMAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4267373-A | HYDROXY- OR -OXY-SUBSTITUTED-6-ALKYL- OR DIALKYLAMINO-7-HYDROXY DERIVATIVES | E. R. SQUIBB & SONS, INC. (US) | 1981-05-12 | — | — | US | disclosed |
| US-4081444-A | Phenylpiperazinotetrahydronaphthols and derivatives | E. R. SQUIBB & SONS, INC. (US) | 1978-03-28 | — | — | US | disclosed |
| US-4076843-A | 5,6,7,8-Tetrahydronaphthalene hypotensive agents | E. R. SQUIBB & SONS, INC. (US) | 1978-02-28 | — | — | US | disclosed |
| US-4018773-A | Phenylpiperazinotetrahydronaphthols and derivatives | E. R. SQUIBB & SONS, INC. (US) | 1977-04-19 | — | — | US | disclosed |